Literature DB >> 16685765

Regulation of voltage-gated Ca2+ channels by calmodulin.

D Brent Halling1, Paula Aracena-Parks, Susan L Hamilton.   

Abstract

Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 andCav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.

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Year:  2006        PMID： 16685765     DOI： 10.1126/stke.3182006er1

Source DB:  PubMed          Journal:  Sci STKE        ISSN： 1525-8882


  51 in total

1.  Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation.

Authors:  Chunyan Pang; Shawn M Crump; Ling Jin; Robert N Correll; Brian S Finlin; Jonathan Satin; Douglas A Andres
Journal:  Channels (Austin)       Date:  2010-05-01       Impact factor: 2.581

2.  C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation.

Authors:  Sébastien Roger; Ludovic Gillet; Alberto Baroja-Mazo; Annmarie Surprenant; Pablo Pelegrin
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157

Review 3.  The ß subunit of voltage-gated Ca2+ channels.

Authors:  Zafir Buraei; Jian Yang
Journal:  Physiol Rev       Date:  2010-10       Impact factor: 37.312

4.  The structural biology of voltage-gated calcium channel function and regulation.

Authors:  F Van Petegem; D L Minor
Journal:  Biochem Soc Trans       Date:  2006-11       Impact factor: 5.407

5.  A mutually induced conformational fit underlies Ca2+-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K+ channels.

Authors:  Crystal R Archer; Benjamin T Enslow; Alexander B Taylor; Victor De la Rosa; Akash Bhattacharya; Mark S Shapiro
Journal:  J Biol Chem       Date:  2019-02-26       Impact factor: 5.157

6.  Cumulative activation of voltage-dependent KVS-1 potassium channels.

Authors:  Patricio Rojas; Jonathan Garst-Orozco; Beravan Baban; Jose Antonio de Santiago-Castillo; Manuel Covarrubias; Lawrence Salkoff
Journal:  J Neurosci       Date:  2008-01-16       Impact factor: 6.167

Review 7.  Supramolecular assemblies and localized regulation of voltage-gated ion channels.

Authors:  Shuiping Dai; Duane D Hall; Johannes W Hell
Journal:  Physiol Rev       Date:  2009-04       Impact factor: 37.312

8.  Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.

Authors:  Felix Findeisen; Christine H Rumpf; Daniel L Minor
Journal:  J Mol Biol       Date:  2013-06-25       Impact factor: 5.469

Review 9.  Regulation of voltage-gated calcium channels by proteolysis.

Authors:  Kathryn Abele; Jian Yang
Journal:  Sheng Li Xue Bao       Date:  2012-10-25

10.  Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1.

Authors:  Shimrit Oz; Adva Benmocha; Yehezkel Sasson; Dana Sachyani; Lior Almagor; Amy Lee; Joel A Hirsch; Nathan Dascal
Journal:  J Biol Chem       Date:  2013-03-25       Impact factor: 5.157
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