Literature DB >> 16684648

Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

Thomas K H Chang1, David J Waxman.   

Abstract

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These transcription factors are predominantly expressed in the liver, where they are activated by structurally diverse compounds, including many drugs and endogenous substances. CAR and PXR regulate the expression of a broad range of genes, which contribute to transcellular transport, bioactivation, and detoxification of numerous xenochemicals and endogenous substances. This article discusses the importance of these receptors for pharmacology and toxicology, emphasizing the role of individual drugs and natural products as agonists, indirect activators, inverse agonists, and antagonists of CAR and PXR.

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Year:  2006        PMID： 16684648     DOI： 10.1080/03602530600569828

Source DB:  PubMed          Journal:  Drug Metab Rev        ISSN： 0360-2532            Impact factor:   4.518


  39 in total

1.  Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine.

Authors:  Devinder Sharma; Aik Jiang Lau; Matthew A Sherman; Thomas K H Chang
Journal:  Br J Pharmacol       Date:  2015-02-10       Impact factor: 8.739

2.  Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands.

Authors:  Ann M Dring; Linnea E Anderson; Saima Qamar; Matthew A Stoner
Journal:  Chem Biol Interact       Date:  2010-10-20       Impact factor: 5.192

3.  Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR.

Authors:  Andy Rampersaud; Nicholas J Lodato; Aram Shin; David J Waxman
Journal:  Toxicol Sci       Date:  2019-06-24       Impact factor: 4.849

4.  Activation of CAR and PXR by Dietary, Environmental and Occupational Chemicals Alters Drug Metabolism, Intermediary Metabolism, and Cell Proliferation.

Authors:  J P Hernandez; L C Mota; W S Baldwin
Journal:  Curr Pharmacogenomics Person Med       Date:  2009-06-01

5.  Ortho-aminoazotoluene activates mouse constitutive androstane receptor (mCAR) and increases expression of mCAR target genes.

Authors:  Mariya A Smetanina; Mariya Y Pakharukova; Svitlana M Kurinna; Bingning Dong; Juan P Hernandez; David D Moore; Tatyana I Merkulova
Journal:  Toxicol Appl Pharmacol       Date:  2011-06-06       Impact factor: 4.219

6.  Widespread Dysregulation of Long Noncoding Genes Associated With Fatty Acid Metabolism, Cell Division, and Immune Response Gene Networks in Xenobiotic-exposed Rat Liver.

Authors:  Kritika Karri; David J Waxman
Journal:  Toxicol Sci       Date:  2020-04-01       Impact factor: 4.849

Review 7.  Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities.

Authors:  Curtis J Omiecinski; John P Vanden Heuvel; Gary H Perdew; Jeffrey M Peters
Journal:  Toxicol Sci       Date:  2010-11-08       Impact factor: 4.849

8.  Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver.

Authors:  Nicholas J Lodato; Tisha Melia; Andy Rampersaud; David J Waxman
Journal:  Toxicol Sci       Date:  2017-09-01       Impact factor: 4.849

9.  Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.

Authors:  Evan D Kharasch; Darain Mitchell; Rebecka Coles; Roberto Blanco
Journal:  Antimicrob Agents Chemother       Date:  2008-02-19       Impact factor: 5.191

10.  The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.

Authors:  Juan P Hernandez; Wendong Huang; Laura M Chapman; Steven Chua; David D Moore; William S Baldwin
Journal:  Toxicol Sci       Date:  2007-05-05       Impact factor: 4.849
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