BACKGROUND/AIMS: Human parvovirus B19 (B19) has been identified in the serum of hepatitis B virus (HBV) infected patients. However, the effect of B19-infection on the course of HBV-associated liver disease has not previously been investigated. We examined the prevalence of B19-DNA in HBV-infected Vietnamese patients and analysed the association between co-infection and the clinical outcome of HBV-infection. METHODS: Serum samples from 399 HBV-infected patients and 64 healthy individuals were analysed for the presence of B19-DNA by PCR and DNA-sequencing. RESULTS: B19-DNA was detected in 99/463 (21.4%) individuals. The proportion of HBV-infected patients who were also co-infected with B19 was higher than the healthy controls (P<0.001). B19-DNA was detected more frequently in patients with HBV-associated hepatocellular carcinoma compared to patients with acute and chronic HBV, HBV-associated liver cirrhosis and healthy subjects (P<0.006). A positive correlation was also found between B19-DNA loads and both serum HBV-DNA loads and alanine aminotransferase (rho>0.250 and P<0.05). CONCLUSIONS: Our findings demonstrate that B19-infection is frequent in HBV-infected Vietnamese patients. Also, a significant correlation exists between HBV/B19 co-infection and a greater likelihood of progression to more severe hepatitis B-associated liver disease. Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis.
BACKGROUND/AIMS: Human parvovirus B19 (B19) has been identified in the serum of hepatitis B virus (HBV) infectedpatients. However, the effect of B19-infection on the course of HBV-associated liver disease has not previously been investigated. We examined the prevalence of B19-DNA in HBV-infected Vietnamese patients and analysed the association between co-infection and the clinical outcome of HBV-infection. METHODS: Serum samples from 399 HBV-infectedpatients and 64 healthy individuals were analysed for the presence of B19-DNA by PCR and DNA-sequencing. RESULTS:B19-DNA was detected in 99/463 (21.4%) individuals. The proportion of HBV-infectedpatients who were also co-infected with B19 was higher than the healthy controls (P<0.001). B19-DNA was detected more frequently in patients with HBV-associated hepatocellular carcinoma compared to patients with acute and chronic HBV, HBV-associated liver cirrhosis and healthy subjects (P<0.006). A positive correlation was also found between B19-DNA loads and both serum HBV-DNA loads and alanine aminotransferase (rho>0.250 and P<0.05). CONCLUSIONS: Our findings demonstrate that B19-infection is frequent in HBV-infected Vietnamese patients. Also, a significant correlation exists between HBV/B19 co-infection and a greater likelihood of progression to more severe hepatitis B-associated liver disease. Further studies are required to determine the role of B19-infection on HBV-associated pathogenesis.
Authors: Trine H Mogensen; Jens Magnus B Jensen; Stephen Hamilton-Dutoit; Carsten S Larsen Journal: BMC Infect Dis Date: 2010-08-20 Impact factor: 3.090
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Authors: Nguyen L Toan; Bui T Sy; Le H Song; Hoang V Luong; Nguyen T Binh; Vu Q Binh; Reinhard Kandolf; Thirumalaisamy P Velavan; Peter G Kremsner; C-Thomas Bock Journal: BMC Infect Dis Date: 2013-08-15 Impact factor: 3.090
Authors: Rogier Bodewes; Ana Rubio García; Lidewij C M Wiersma; Sarah Getu; Martijn Beukers; Claudia M E Schapendonk; Peter R W A van Run; Marco W G van de Bildt; Marjolein J Poen; Nynke Osinga; Guillermo J Sánchez Contreras; Thijs Kuiken; Saskia L Smits; Albert D M E Osterhaus Journal: PLoS One Date: 2013-11-05 Impact factor: 3.240