| Literature DB >> 16682795 |
Corina Pennanen1, Cristina Testa, Marina Boccardi, Mikko P Laakso, Merja Hallikainen, Eeva-Liisa Helkala, Tuomo Hänninen, Miia Kivipelto, Mervi Könönen, Aulikki Nissinen, Susanna Tervo, Matti Vanhanen, Ritva Vanninen, Giovani B Frisoni, Hilkka Soininen.
Abstract
We investigated the effect of apolipoprotein E (ApoE) on the whole brain in 51 individuals with mild cognitive impairment using voxel-based morphometry. Between cases heterozygous for the ApoE epsilon4 (n = 15) and those who were ApoE epsilon4 noncarriers (n = 28), only the right parahippocampal gyrus, with the entorhinal cortex included, reached the level of statistical significance. In cases homozygous for the epsilon4 allele (n = 8) versus noncarriers, the greatest atrophy was located in the right amygdala followed by the right parahippocampal gyrus, the left amygdala and the left medial dorsal thalamic nucleus.Entities:
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Year: 2006 PMID： 16682795 DOI： 10.1159/000093263
Source DB: PubMed Journal: Dement Geriatr Cogn Disord ISSN： 1420-8008 Impact factor: 2.959