Literature DB >> 16682766

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.

Mário T Murakami1, Cristiane C Melo, Yamileth Angulo, Bruno Lomonte, Raghuvir K Arni.   

Abstract

Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Since the structural basis for their toxic activity is still only partially understood, the structure of myotoxin II, a monomeric Lys49 PLA2 homologue from Atropoides nummifer, has been determined at 2.08 angstroms resolution and the anion-binding site has been characterized.

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Year:  2006        PMID： 16682766      PMCID： PMC2219968          DOI： 10.1107/S1744309106010700

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  29 in total

1.  A clinical and epidemiologic study of 292 cases of lance-headed viper bite in a Brazilian teaching hospital.

Authors:  S de A Nishioka; P V Silveira
Journal:  Am J Trop Med Hyg       Date:  1992-12       Impact factor: 2.345

2.  Inhibition of myotoxic activity of Bothrops asper myotoxin II by the anti-trypanosomal drug suramin.

Authors:  Mário T Murakami; Emerson Z Arruda; Paulo A Melo; Ana B Martinez; Sabrińa Calil-Eliás; Marcelo A Tomaz; Bruno Lomonte; José M Gutiérrez; Raghuvir K Arni
Journal:  J Mol Biol       Date:  2005-07-15       Impact factor: 5.469

3.  A predominant role for hydrogen bonding in the stability of the homodimer of bothropstoxin-I, A lysine 49-phospholipase A2.

Authors:  R Ruller; E A Aragão; L Chioato; T Lopes Ferreira; A H C de Oliveira; J M Sà; R J Ward
Journal:  Biochimie       Date:  2005-11       Impact factor: 4.079

4.  Identification of vascular endothelial growth factor receptor-binding protein in the venom of eastern cottonmouth. A new role of snake venom myotoxic Lys49-phospholipase A2.

Authors:  Yasuo Yamazaki; Yukiko Matsunaga; Yuta Nakano; Takashi Morita
Journal:  J Biol Chem       Date:  2005-07-13       Impact factor: 5.157

5.  Geographical distribution of Viperidae, Elapidae and Hydrophidae in Costa Rica.

Authors:  R T Taylor; A Flores; G Flores; R Bolaños
Journal:  Rev Biol Trop       Date:  1973-12       Impact factor: 0.723

6.  Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.

Authors:  Yamileth Angulo; José María Gutiérrez; Andreimar M Soares; Wonhwa Cho; Bruno Lomonte
Journal:  Toxicon       Date:  2005-09-01       Impact factor: 3.033

7.  A pH-induced dissociation of the dimeric form of a lysine 49-phospholipase A2 abolishes Ca2+-independent membrane damaging activity.

Authors:  A H de Oliveira; J R Giglio; S H Andrião-Escarso; A S Ito; R J Ward
Journal:  Biochemistry       Date:  2001-06-12       Impact factor: 3.162

8.  A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom.

Authors:  R Renetseder; S Brunie; B W Dijkstra; J Drenth; P B Sigler
Journal:  J Biol Chem       Date:  1985-09-25       Impact factor: 5.157

Review 9.  Myotoxic components of snake venoms: their biochemical and biological activities.

Authors:  D Mebs; C L Ownby
Journal:  Pharmacol Ther       Date:  1990       Impact factor: 12.310

10.  Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorus.

Authors:  D L Scott; A Achari; J C Vidal; P B Sigler
Journal:  J Biol Chem       Date:  1992-11-05       Impact factor: 5.157
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  2 in total

1.  Crystallization and preliminary X-ray diffraction analysis of a novel Arg49 phospholipase A2 homologue from Zhaoermia mangshanensis venom.

Authors:  Mário T Murakami; Ulrich Kuch; Dietrich Mebs; Raghuvir K Arni
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2007-06-22

2.  SDS-induced oligomerization of Lys49-phospholipase A2 from snake venom.

Authors:  Takashi Matsui; Shizuka Kamata; Kentaro Ishii; Takahiro Maruno; Nouran Ghanem; Susumu Uchiyama; Koichi Kato; Atsuo Suzuki; Naoko Oda-Ueda; Tomohisa Ogawa; Yoshikazu Tanaka
Journal:  Sci Rep       Date:  2019-02-20       Impact factor: 4.379
  2 in total

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