| Literature DB >> 16682640 |
Amy M Hicks1, Gregory Riedlinger, Mark C Willingham, Martha A Alexander-Miller, C Von Kap-Herr, Mark J Pettenati, Anne M Sanders, Holly M Weir, Wei Du, Joseph Kim, Andrew J G Simpson, Lloyd J Old, Zheng Cui.
Abstract
Spontaneous regression/complete resistance (SR/CR) mice resist very high doses of cancer cells that are lethal to WT mice even at low doses. In this study, we show that this resistance is mediated by rapid infiltration of leukocytes, mostly of innate immunity, in both primary and repeated challenges. Formation of rosettes with infiltrating natural killer cells, neutrophils, and macrophages was required for the subsequent destruction of cancer cells through rapid cytolysis. Highly purified natural killer cells, macrophages, and neutrophils from the SR/CR mice independently killed cancer cells in vitro. The independent killing activity by each subset of effector cells is consistent with the observation that the resistance was abolished by depleting total infiltrating leukocytes but not by depleting only one or two subsets of leukocytes. The resistance was completely transferable to WT recipient mice through SR/CR splenocytes, bone marrow cells, or enriched peritoneal macrophages, either for prevention against subsequent cancer challenges or eradication of established malignancy at distant sites.Entities:
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Year: 2006 PMID： 16682640 PMCID： PMC1458507 DOI： 10.1073/pnas.0602382103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205