| Literature DB >> 16682206 |
Yukio Kitade1, Takayuki Ando, Tsuyoshi Yamaguchi, Ayumi Hori, Masayuki Nakanishi, Yoshihito Ueno.
Abstract
4'-Fluorinated analogue of 9-[(1'R,2'S,3'R)-2',3'-dihydroxy-cyclopentan-1'-yl]adenine (DHCaA) and their related analogues were systematically synthesized under the Mitsunobu and palladium(0) coupling conditions followed by fluorination with inversion of the configuration by using diethylaminosulfur trifluoride, respectively. 4'-beta-Fluoro DHCaA and 2-amino-4'-alpha-fluoro DHCaA demonstrated slight inhibitory activity against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase, respectively.Entities:
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Year: 2006 PMID： 16682206 DOI： 10.1016/j.bmc.2006.04.023
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641