| Literature DB >> 16682193 |
Jagabandhu Das1, Joseph A Furch, Chunjian Liu, Robert V Moquin, James Lin, Steven H Spergel, Kim W McIntyre, David J Shuster, Kathleen D O'Day, Becky Penhallow, Chen-Yi Hung, Arthur M Doweyko, Amrita Kamath, Hongjian Zhang, Punit Marathe, Steven B Kanner, Tai-An Lin, John H Dodd, Joel C Barrish, John Wityak.
Abstract
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity, and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 3 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo and was previously reported to reduce lung inflammation in a mouse model of ovalbumin induced allergy/asthma.Entities:
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Year: 2006 PMID： 16682193 DOI： 10.1016/j.bmcl.2006.04.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823