Literature DB >> 16680325

Comparative analysis between osteosarcoma and Ewing's sarcoma: evaluation of the time from onset of signs and symptoms until diagnosis.

Raquel Bezerra Guerra1, Marcelo Duarte Tostes, Leandro da Costa Miranda, Olavo Pires de Camargo, André Mathias Baptista, Marcelo Tadeu Caiero, Telma Muria Dos Santos Machado, Márcia Datz Abadi, Claudia Regina G C M Mendes de Oliveira, Renée Zon Filippi.   

Abstract

OBJECTIVE: The purposes of this study were to describe the early signs and symptoms of osteosarcoma and Ewing's sarcoma, identify symptoms that could be used to help differentiate the two types of tumors, and determine the time elapsed between the onset of signs and symptoms and the definitive diagnosis in our service, providing information and imputus for earlier diagnosis of these tumors.
METHODS: A retrospective analysis of the medical dossiers of 365 patients under 30 years of age diagnosed with osteosarcoma or Ewing's sarcoma was performed, and the aspects of the clinical diagnosis were statistically analyzed and compared.
RESULTS: The time between the onset of signs and the symptoms was 5.25 months for osteosarcoma and 8.1 months for Ewing's sarcoma, and the most frequent (89.5%) early symptom of osteosarcoma and Ewing's sarcoma was local pain. Symptoms that might aid diagnosis included early local volume increase and the presence of fever.
CONCLUSION: The time until diagnosis of both neoplasias was higher than that reported for North America and Europe. Education of the lay public and medical professionals regarding suspicious early signs and symptoms might shorten the delay of diagnosis.

Entities:  

Mesh:

Year:  2006        PMID: 16680325     DOI: 10.1590/s1807-59322006000200003

Source DB:  PubMed          Journal:  Clinics (Sao Paulo)        ISSN: 1807-5932            Impact factor:   2.365


  9 in total

1.  Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma. A cross sectional study.

Authors:  Achmad Fauzi Kamal; Irsan Abubakar; Thariqah Salamah
Journal:  Ann Med Surg (Lond)       Date:  2021-03-16

2.  Osteosarcoma in the distal femur two years after an ipsilateral femoral shaft fracture: a case report.

Authors:  Oscar Dorrestijn; Paul C Jutte
Journal:  J Med Case Rep       Date:  2011-05-21

3.  Chondroblastic osteosarcoma.

Authors:  Etanaiara Almeida; Bruno Araújo Mascarenhas; Arlei Cerqueira; Alena Ribeiro Alves Peixoto Medrado
Journal:  J Oral Maxillofac Pathol       Date:  2014 Sep-Dec

4.  Prognostic factors to survival of patients with chondroblastic osteosarcoma.

Authors:  Hui-Hui Sun; Xiang-Yang Chen; Jia-Qu Cui; Zhao-Ming Zhou; Kai-Jin Guo
Journal:  Medicine (Baltimore)       Date:  2018-09       Impact factor: 1.889

5.  The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes.

Authors:  Vicky Soomers; Olga Husson; Robin Young; Ingrid Desar; Winette Van der Graaf
Journal:  ESMO Open       Date:  2020-02

6.  Delay in diagnosis of primary osteosarcoma of bone in children: Have we improved in the last 15 years and what is the impact of delay on diagnosis?

Authors:  Shinichirou Yoshida; James Celaire; Chloe Pace; Charles Taylor; Yoichi Kaneuchi; Scott Evans; Adesegun Abudu
Journal:  J Bone Oncol       Date:  2021-03-29       Impact factor: 4.072

7.  Prognostic factors in the survival of patients diagnosed with primary non-metastatic osteosarcoma with a poor response to neoadjuvant chemotherapy.

Authors:  Rosalvo Zósimo Bispo Júnior; Olavo Pires de Camargo
Journal:  Clinics (Sao Paulo)       Date:  2009       Impact factor: 2.365

8.  Do malignant bone tumors of the foot have a different biological behavior than sarcomas at other skeletal sites?

Authors:  M Brotzmann; F Hefti; D Baumhoer; A H Krieg
Journal:  Sarcoma       Date:  2013-03-20

9.  Prognostic factors of chondroblastic osteosarcoma and nomogram development for prediction: A population-based, STROBE-compliant study.

Authors:  Cheng Peng; Yingjie Hao; Zhinan Ren; Guangduo Zhu; Lei Yu
Journal:  Medicine (Baltimore)       Date:  2021-06-11       Impact factor: 1.817

  9 in total

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