Literature DB >> 16679731

Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis.

Taekyun Shin1, Meejung Ahn, Heechul Kim, Hyung-Min Kim, Yoh Matsumoto.   

Abstract

The expression of osteopontin (OPN) in the hearts of rats with experimental autoimmune myocarditis (EAM) was evaluated. Western blot analysis showed that OPN was significantly increased in the hearts with EAM compared with those of complete Freund's adjuvant (CFA) immunized control. Immunohistochemically, OPN was weakly expressed in the cardiomyocytes in the heart with normal and CFA immunized controls. In EAM lesions, OPN was intensely immunostained in some inflammatory cells, mainly ED1 positive macrophages. These findings suggest that OPN is significantly increased in EAM lesions and that OPN mediates the inflammatory process in the course of rat EAM model.

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Year:  2006        PMID： 16679731     DOI： 10.1292/jvms.68.379

Source DB:  PubMed          Journal:  J Vet Med Sci        ISSN： 0916-7250            Impact factor:   1.267


  6 in total

1.  Osteopontin promotes fibrosis in dystrophic mouse muscle by modulating immune cell subsets and intramuscular TGF-beta.

Authors:  Sylvia A Vetrone; Encarnacion Montecino-Rodriguez; Elena Kudryashova; Irina Kramerova; Eric P Hoffman; Scot D Liu; M Carrie Miceli; Melissa J Spencer
Journal:  J Clin Invest       Date:  2009-05-18       Impact factor: 14.808

2.  Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.

Authors:  Gopal Murugaiyan; Akanksha Mittal; Howard L Weiner
Journal:  J Immunol       Date:  2008-12-01       Impact factor: 5.422

3.  Role of osteopontin in calcification in autoimmune pancreatitis.

Authors:  Hiroki Takada; Takahiro Nakazawa; Hirotaka Ohara; Tomoaki Ando; Kazuki Hayashi; Itaru Naito; Fumihiro Okumura; Hajime Tanaka; Tamaki Yamada; Satoru Takahashi; Takashi Joh
Journal:  Dig Dis Sci       Date:  2008-07-24       Impact factor: 3.199

4.  Modulation of endoplasmic reticulum stress and cardiomyocyte apoptosis by mulberry leaf diet in experimental autoimmune myocarditis rats.

Authors:  Somasundaram Arumugam; Rajarajan A Thandavarayan; Punniyakoti T Veeraveedu; Meilei Ma; Vijayasree V Giridharan; Wawaimuli Arozal; Flori R Sari; Vijayakumar Sukumaran; Arunprasath Lakshmanan; Vivian Soetikno; Kenji Suzuki; Makoto Kodama; Kenichi Watanabe
Journal:  J Clin Biochem Nutr       Date:  2011-11-18       Impact factor: 3.114

5.  Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis.

Authors:  Vijayakumar Sukumaran; Kenichi Watanabe; Punniyakoti T Veeraveedu; Narasimman Gurusamy; Meilei Ma; Rajarajan A Thandavarayan; Arun Prasath Lakshmanan; Ken'ichi Yamaguchi; Kenji Suzuki; Makoto Kodama
Journal:  Int J Biol Sci       Date:  2011-02-11       Impact factor: 6.580

6.  The Role of Osteopontin and Its Gene on Glucocorticoid Response in Myasthenia Gravis.

Authors:  Yanchen Xie; Hai-Feng Li; Liang Sun; Linda L Kusner; Shuhui Wang; Yunxiao Meng; Xu Zhang; Yu Hong; Xiang Gao; Yao Li; Henry J Kaminski
Journal:  Front Neurol       Date:  2017-05-31       Impact factor: 4.003
  6 in total

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