| Literature DB >> 16679028 |
B Simizu1, S Abe, H Yamamoto, Y Tano, Y Ota, M Miyazawa, H Horie, K Satoh, K Wakabayashi.
Abstract
In the course of Sabin-inactivated poliovirus vaccine (S-IPV) development, we have established high-yield virus production techniques based on Vero cell micro-carrier cultures. Development of specific ELISA tests to quantify the antigen content of S-IPV has been achieved. To adjust the immunogenicity of S-IPV so as to be comparable with the conventional-IPV, a new formulation was determined using a potency test using rats. The reformulated S-IPV was shown to be efficacious for the immunization of monkeys.Entities:
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Year: 2006 PMID： 16679028 DOI： 10.1016/j.biologicals.2006.02.010
Source DB: PubMed Journal: Biologicals ISSN： 1045-1056 Impact factor: 1.856