Jianguang Ji1, Kari Hemminki. 1. Department of Bioscience at Novum, Karolinska Institute, Huddinge, Sweden. jianguang.ji@biosci.ki.se
Abstract
BACKGROUND AND AIMS: Familial risks for esophageal cancer are not well known, especially for specific histologic types. METHODS: We used the nationwide Swedish Family-Cancer Database to examine familial risks for esophageal cancer in offspring. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were used to calculate the risk. Age standardized incidence rates for specific histology types of esophageal cancer were available from Swedish Cancer Registry. RESULTS: The incidence of male squamous cell carcinoma (SCC) reached its peak rate in 1985 and decreased afterwards. The incidence of adenocarcinoma exceeded that of SCC in 2000 among men. The SIR for offspring esophageal cancer was significantly increased when a parent presented with esophageal cancer (SIR, 2.60). The SIRs for adenocarcinoma were 4.05 and 3.52 when a parent was diagnosed with SCC and any esophageal cancer, respectively; from maternal probands the SIRs were 10.47 and 7.74, respectively. The familial SIR was above unity but not significant for SCC. For associations with other cancer sites, SCC showed a significantly increased risk when a sibling had lung cancer (SIR, 2.52). CONCLUSIONS: The present study showed that adenocarcinoma became the major histologic type of esophageal cancer in Swedish men around 2000. For the first time we could show that familial risks of esophageal adenocarcinoma were increased when parents presented with esophageal cancer (particularly SCC). The high risk for adenocarcinoma in such families might be due to heritable effects. However, because of the limited number of familial cases, the results should be interpreted with caution.
BACKGROUND AND AIMS: Familial risks for esophageal cancer are not well known, especially for specific histologic types. METHODS: We used the nationwide Swedish Family-Cancer Database to examine familial risks for esophageal cancer in offspring. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were used to calculate the risk. Age standardized incidence rates for specific histology types of esophageal cancer were available from Swedish Cancer Registry. RESULTS: The incidence of male squamous cell carcinoma (SCC) reached its peak rate in 1985 and decreased afterwards. The incidence of adenocarcinoma exceeded that of SCC in 2000 among men. The SIR for offspring esophageal cancer was significantly increased when a parent presented with esophageal cancer (SIR, 2.60). The SIRs for adenocarcinoma were 4.05 and 3.52 when a parent was diagnosed with SCC and any esophageal cancer, respectively; from maternal probands the SIRs were 10.47 and 7.74, respectively. The familial SIR was above unity but not significant for SCC. For associations with other cancer sites, SCC showed a significantly increased risk when a sibling had lung cancer (SIR, 2.52). CONCLUSIONS: The present study showed that adenocarcinoma became the major histologic type of esophageal cancer in Swedish men around 2000. For the first time we could show that familial risks of esophageal adenocarcinoma were increased when parents presented with esophageal cancer (particularly SCC). The high risk for adenocarcinoma in such families might be due to heritable effects. However, because of the limited number of familial cases, the results should be interpreted with caution.
Authors: Jennifer Drahos; Qian Xiao; Harvey A Risch; Neal D Freedman; Christian C Abnet; Lesley A Anderson; Leslie Bernstein; Linda Brown; Wong-Ho Chow; Marilie D Gammon; Farin Kamangar; Linda M Liao; Liam J Murray; Mary H Ward; Weimin Ye; Anna H Wu; Thomas L Vaughan; David C Whiteman; Michael B Cook Journal: Int J Cancer Date: 2015-08-26 Impact factor: 7.396
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Federico Canzian; Alfredo Carrato; Tania Carreon; Angela Carta; John K C Chan; Ellen T Chang; Gee-Chen Chang; I-Shou Chang; Jiang Chang; Jenny Chang-Claude; Chien-Jen Chen; Chih-Yi Chen; Chu Chen; Chung-Hsing Chen; Constance Chen; Hongyan Chen; Kexin Chen; Kuan-Yu Chen; Kun-Chieh Chen; Ying Chen; Ying-Hsiang Chen; Yi-Song Chen; Yuh-Min Chen; Li-Hsin Chien; María-Dolores Chirlaque; Jin Eun Choi; Yi Young Choi; Wong-Ho Chow; Charles C Chung; Jacqueline Clavel; Françoise Clavel-Chapelon; Pierluigi Cocco; Joanne S Colt; Eva Comperat; Lucia Conde; Joseph M Connors; David Conti; Victoria K Cortessis; Michelle Cotterchio; Wendy Cozen; Simon Crouch; Marta Crous-Bou; Olivier Cussenot; Faith G Davis; Ti Ding; W Ryan Diver; Miren Dorronsoro; Laure Dossus; Eric J Duell; Maria Grazia Ennas; Ralph L Erickson; Maria Feychting; Adrienne M Flanagan; Lenka Foretova; Joseph F Fraumeni; Neal D Freedman; Laura E Beane Freeman; Charles Fuchs; Manuela Gago-Dominguez; Steven Gallinger; Yu-Tang Gao; Susan M Gapstur; Montserrat Garcia-Closas; Reina García-Closas; Randy D Gascoyne; Julie Gastier-Foster; Mia M Gaudet; J Michael Gaziano; Carol Giffen; Graham G Giles; Edward Giovannucci; Bengt Glimelius; Michael Goggins; Nalan Gokgoz; Alisa M Goldstein; Richard Gorlick; Myron Gross; Robert Grubb; Jian Gu; Peng Guan; Marc Gunter; Huan Guo; Thomas M Habermann; Christopher A Haiman; Dina Halai; Goran Hallmans; Manal Hassan; Claudia Hattinger; Qincheng He; Xingzhou He; Kathy Helzlsouer; Brian Henderson; Roger Henriksson; Henrik Hjalgrim; Judith Hoffman-Bolton; Chancellor Hohensee; Theodore R Holford; Elizabeth A Holly; Yun-Chul Hong; Robert N Hoover; Pamela L Horn-Ross; G M Monawar Hosain; H Dean Hosgood; Chin-Fu Hsiao; Nan Hu; Wei Hu; Zhibin Hu; Ming-Shyan Huang; Jose-Maria Huerta; Jen-Yu Hung; Amy Hutchinson; Peter D Inskip; Rebecca D Jackson; Eric J Jacobs; Mazda Jenab; Hyo-Sung Jeon; Bu-Tian Ji; Guangfu Jin; Li Jin; Christoffer Johansen; Alison Johnson; Yoo Jin Jung; Rudolph Kaaks; Aruna Kamineni; Eleanor Kane; Chang Hyun Kang; Margaret R Karagas; Rachel S Kelly; Kay-Tee Khaw; Christopher Kim; Hee Nam Kim; Jin Hee Kim; Jun Suk Kim; Yeul Hong Kim; Young Tae Kim; Young-Chul Kim; Cari M Kitahara; Alison P Klein; Robert J Klein; Manolis Kogevinas; Takashi Kohno; Laurence N Kolonel; Charles Kooperberg; Anne Kricker; Vittorio Krogh; Hideo Kunitoh; Robert C Kurtz; Sun-Seog Kweon; Andrea LaCroix; Charles Lawrence; Fernando Lecanda; Victor Ho Fun Lee; Donghui Li; Haixin Li; Jihua Li; Yao-Jen Li; Yuqing Li; Linda M Liao; Mark Liebow; Tracy Lightfoot; Wei-Yen Lim; Chien-Chung Lin; Dongxin Lin; Sara Lindstrom; Martha S Linet; Brian K Link; Chenwei Liu; Jianjun Liu; Li Liu; Börje Ljungberg; Josep Lloreta; Simonetta Di Lollo; Daru Lu; Eiluv Lund; Nuria Malats; Satu Mannisto; Loic Le Marchand; Neyssa Marina; Giovanna Masala; Giuseppe Mastrangelo; Keitaro Matsuo; Marc Maynadie; James McKay; Roberta McKean-Cowdin; Mads Melbye; Beatrice S Melin; Dominique S Michaud; Tetsuya Mitsudomi; Alain Monnereau; Rebecca Montalvan; Lee E Moore; Lotte Maxild Mortensen; Alexandra Nieters; Kari E North; Anne J Novak; Ann L Oberg; Kenneth Offit; In-Jae Oh; Sara H Olson; Domenico Palli; William Pao; In Kyu Park; Jae Yong Park; Kyong Hwa Park; Ana Patiño-Garcia; Sofia Pavanello; Petra H M Peeters; Reury-Perng Perng; Ulrike Peters; Gloria M Petersen; Piero Picci; Malcolm C Pike; Stefano Porru; Jennifer Prescott; Ludmila Prokunina-Olsson; Biyun Qian; You-Lin Qiao; Marco Rais; Elio Riboli; Jacques Riby; Harvey A Risch; Cosmeri Rizzato; Rebecca Rodabough; Eve Roman; Morgan Roupret; Avima M Ruder; Silvia de Sanjose; Ghislaine Scelo; Alan Schned; Fredrick Schumacher; Kendra Schwartz; Molly Schwenn; Katia Scotlandi; Adeline Seow; Consol Serra; Massimo Serra; Howard D Sesso; Veronica Wendy Setiawan; Gianluca Severi; Richard K Severson; Tait D Shanafelt; Hongbing Shen; Wei Shen; Min-Ho Shin; Kouya Shiraishi; Xiao-Ou Shu; Afshan Siddiq; Luis Sierrasesúmaga; Alan Dart Loon Sihoe; Christine F Skibola; Alex Smith; Martyn T Smith; Melissa C Southey; John J Spinelli; Anthony Staines; Meir Stampfer; Marianna C Stern; Victoria L Stevens; Rachael S Stolzenberg-Solomon; Jian Su; Wu-Chou Su; Malin Sund; Jae Sook Sung; Sook Whan Sung; Wen Tan; Wei Tang; Adonina Tardón; David Thomas; Carrie A Thompson; Lesley F Tinker; Roberto Tirabosco; Anne Tjønneland; Ruth C Travis; Dimitrios Trichopoulos; Fang-Yu Tsai; Ying-Huang Tsai; Margaret Tucker; Jenny Turner; Claire M Vajdic; Roel C H Vermeulen; Danylo J Villano; Paolo Vineis; Jarmo Virtamo; Kala Visvanathan; Jean Wactawski-Wende; Chaoyu Wang; Chih-Liang Wang; Jiu-Cun Wang; Junwen Wang; Fusheng Wei; Elisabete Weiderpass; George J Weiner; Stephanie Weinstein; Nicolas Wentzensen; Emily White; Thomas E Witzig; Brian M Wolpin; Maria Pik Wong; Chen Wu; Guoping Wu; Junjie Wu; Tangchun Wu; Wei Wu; Xifeng Wu; Yi-Long Wu; Jay S Wunder; Yong-Bing Xiang; Jun Xu; Ping Xu; Pan-Chyr Yang; Tsung-Ying Yang; Yuanqing Ye; Zhihua Yin; Jun Yokota; Ho-Il Yoon; Chong-Jen Yu; Herbert Yu; Kai Yu; Jian-Min Yuan; Andrew Zelenetz; 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Authors: Victoria M Villaflor; Marco E Allaix; Bruce Minsky; Fernando A Herbella; Marco G Patti Journal: World J Gastroenterol Date: 2012-12-14 Impact factor: 5.742