Literature DB >> 16678128

Solution conformation of a neuronal nicotinic acetylcholine receptor antagonist alpha-conotoxin OmIA that discriminates alpha3 vs. alpha6 nAChR subtypes.

Seung-Wook Chi1, Do-Hyoung Kim, Baldomero M Olivera, J Michael McIntosh, Kyou-Hoon Han.   

Abstract

alpha-Conotoxin OmIA from Conus omaria is the only alpha-conotoxin that shows a approximately 20-fold higher affinity to the alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy. alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5)-Asn(12) forming an alpha-helix. Structural features of alpha-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16678128     DOI： 10.1016/j.bbrc.2006.04.099

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins.

Authors:  Tse Siang Kang; Zoran Radić; Todd T Talley; Seetharama D S Jois; Palmer Taylor; R Manjunatha Kini
Journal:  Biochemistry       Date:  2007-02-22       Impact factor: 3.162

2.  alpha4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors.

Authors:  Can Peng; Yuhong Han; Tanya Sanders; Geoffrey Chew; Jing Liu; Edward Hawrot; Chengwu Chi; Chunguang Wang
Journal:  Peptides       Date:  2008-06-07       Impact factor: 3.750

3.  Alpha-conotoxin OmIA is a potent ligand for the acetylcholine-binding protein as well as alpha3beta2 and alpha7 nicotinic acetylcholine receptors.

Authors:  Todd T Talley; Baldomero M Olivera; Kyou-Hoon Han; Sean B Christensen; Cheryl Dowell; Igor Tsigelny; Kwok-Yiu Ho; Palmer Taylor; J Michael McIntosh
Journal:  J Biol Chem       Date:  2006-06-27       Impact factor: 5.157

4.  PeIA-5466: A Novel Peptide Antagonist Containing Non-natural Amino Acids That Selectively Targets α3β2 Nicotinic Acetylcholine Receptors.

Authors:  Arik J Hone; Fernando Fisher; Sean Christensen; Joanna Gajewiak; David Larkin; Paul Whiteaker; J Michael McIntosh
Journal:  J Med Chem       Date:  2019-06-27       Impact factor: 7.446

5.  Atypical alpha-conotoxin LtIA from Conus litteratus targets a novel microsite of the alpha3beta2 nicotinic receptor.

Authors:  Sulan Luo; Kalyana Bharati Akondi; Dongting Zhangsun; Yong Wu; Xiaopeng Zhu; Yuanyan Hu; Sean Christensen; Cheryl Dowell; Norelle L Daly; David J Craik; Ching-I Anderson Wang; Richard J Lewis; Paul F Alewood; J Michael McIntosh
Journal:  J Biol Chem       Date:  2010-02-09       Impact factor: 5.157

Review 6.  Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors.

Authors:  Layla Azam; J Michael McIntosh
Journal:  Acta Pharmacol Sin       Date:  2009-05-18       Impact factor: 6.150

7.  Acetylcholine promotes binding of α-conotoxin MII at α3 β2 nicotinic acetylcholine receptors.

Authors:  Somisetti V Sambasivarao; Jessica Roberts; Vivek S Bharadwaj; Jason G Slingsby; Conrad Rohleder; Chris Mallory; James R Groome; Owen M McDougal; C Mark Maupin
Journal:  Chembiochem       Date:  2014-01-13       Impact factor: 3.164

8.  The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site.

Authors:  Alican Gulsevin; Roger L Papke; Clare Stokes; Hue N T Tran; Aihua H Jin; Irina Vetter; Jens Meiler
Journal:  Toxins (Basel)       Date:  2021-08-10       Impact factor: 4.546
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.