| Literature DB >> 16677861 |
M A Stukova1, S Sereinig, N V Zabolotnyh, B Ferko, C Kittel, J Romanova, T I Vinogradova, H Katinger, O I Kiselev, A Egorov.
Abstract
We generated several attenuated recombinant influenza A vectors expressing the Mycobacterium tuberculosis early secretory antigenic target (ESAT-6) protein. The ESAT-6 protein was recently identified as one of the most promising protective antigens for cell-mediated immunity. The obtained vectors appeared to be capable of inducing ESAT-6 specific Th1 immune response in mice after intranasal immunization. We found that double immunization with two influenza vectors of different subtypes provided a significant level of protection in mice, when applied as prophylactic vaccine, as well as substantial therapeutic effect in mice with pre-established tuberculosis infection. Moreover, we found a strong synergistic effect when vaccination with Flu/ESAT-6 vectors was combined with isoniazid treatment, resulting in a dramatic reduction of bacterial load in the lungs of infected mice.Entities:
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Year: 2006 PMID： 16677861 DOI： 10.1016/j.tube.2006.01.010
Source DB: PubMed Journal: Tuberculosis (Edinb) ISSN： 1472-9792 Impact factor: 3.131