| Literature DB >> 16677755 |
Sandra Costa1, Daniela Pinto, Deolinda Pereira, André Vasconcelos, Carlos Afonso-Lopes, Teresa Osório, Carlos Lopes, Rui Medeiros.
Abstract
The purpose of this study was to evaluate the role of XPD genotypes as genetic indicator of susceptibility to ovarian cancer. We have used a case-control study. We analysed DNA samples from 141 ovarian cancer patients and 202 control subjects, for three XPD polymorphisms using PCR-RFLP. We observed that Asn312Asn XPD genotype carriers have increased susceptibility of ovarian cancer (OR=2.46 95% CI 1.20-5.06; P=0.015). Furthermore, we found that carriers of Gln751Gln XPD genotype have an increased susceptibility of ovarian cancer (OR=3.40 95% CI 1.61-7.15; P=0.001). Asn312Asn and Gln751Gln are particularly associated with an early-stage of disease. Our results suggest an important role for Asn312Asn and Gln751Gln XPD polymorphisms in the susceptibility to ovarian cancer.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16677755 DOI： 10.1016/j.canlet.2006.03.014
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679