Literature DB >> 16677093

Regulation by the cAMP cascade of oxygen free radical balance in mammalian cells.

F Bellomo1, C Piccoli, T Cocco, S Scacco, F Papa, A Gaballo, D Boffoli, A Signorile, A D'Aprile, R Scrima, A M Sardanelli, N Capitanio, S Papa.   

Abstract

A study is presented of the effect of the cAMP cascade on oxygen metabolism in mammalian cell cultures. Serum-starvation of the cell cultures resulted in depression of the forward NADH-ubiquinone oxidoreductase activity of complex I, decreased content of glutathione, and enhancement of the cellular level of H2O2. Depressed transcription of cytosolic Cu/Zn-SOD 1, mitochondrial glutathione peroxidase and catalase was also observed. Activation of the cAMP cascade reversed the depression of the activity of complex I and the accumulation of H2O2. The effect of cAMP involved the cAMP-dependent protein kinase.

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Year:  2006        PMID： 16677093     DOI： 10.1089/ars.2006.8.495

Source DB:  PubMed          Journal:  Antioxid Redox Signal        ISSN： 1523-0864            Impact factor:   8.401


  12 in total

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