Literature DB >> 16676416

Therapeutic potential of folate uptake inhibition in Plasmodium falciparum.

Alexis M Nzila1, Gilbert Kokwaro, Peter A Winstanley, Kevin Marsh, Steve A Ward.   

Abstract

Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. This article provides the evidence indicating that sulfadoxine-pyrimethamine resistance can be reversed in vitro and discusses how this information might be exploited to extend the therapeutic lifetime of sulfadoxine-pyrimethamine in vivo.

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Year:  2004        PMID： 16676416     DOI： 10.1016/j.pt.2003.12.005

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  5 in total

Review 1.  Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.

Authors:  Alexis Nzila; Steve A Ward; Kevin Marsh; Paul F G Sims; John E Hyde
Journal:  Trends Parasitol       Date:  2005-07

Review 2.  Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.

Authors:  Anthony O Gaca; José A Lemos
Journal:  Microbiol Mol Biol Rev       Date:  2019-07-17       Impact factor: 11.056

Review 3.  Targeting purine and pyrimidine metabolism in human apicomplexan parasites.

Authors:  John E Hyde
Journal:  Curr Drug Targets       Date:  2007-01       Impact factor: 3.465

4.  Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.

Authors:  Sabina Dahlström; M Isabel Veiga; Andreas Mårtensson; Anders Björkman; J Pedro Gil
Journal:  Antimicrob Agents Chemother       Date:  2009-04-13       Impact factor: 5.191

Review 5.  Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

Authors:  Julie Gutman; S Patrick Kachur; Laurence Slutsker; Alexis Nzila; Theonest Mutabingwa
Journal:  Malar J       Date:  2012-02-09       Impact factor: 2.979
  5 in total

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