BACKGROUND: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity. AIM: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. MATERIAL AND METHODS: A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) (3) 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample. RESULTS: After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate. CONCLUSIONS: Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgens.
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BACKGROUND: Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivity. AIM: To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. MATERIAL AND METHODS: A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) (3) 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample. RESULTS: After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate. CONCLUSIONS: Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgens.
Authors: Razieh Hosseini; Farzaneh Montazerifar; Elham Shahraki; Mansour Karajibani; Ali Mohammad Mokhtari; Ali Reza Dashipour; Gordon A Ferns; Mohammad Jalali Journal: Biol Trace Elem Res Date: 2021-03-03 Impact factor: 3.738