BACKGROUND AND PURPOSE: The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke. Recent evidence suggests that uric acid may be an important causal agent in cardiovascular disease, for example, by inducing renal disease and hence hypertension. We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study. METHODS: The study was based on 4385 participants of the Rotterdam Study who, at baseline (1990 to 1993), were > or =55 years of age, free from stroke and coronary heart disease, and had blood taken. Follow-up for incident stroke and myocardial infarction was complete until January 1, 2002. Data were analyzed with Cox proportional hazards models with adjustment for relevant confounders. RESULTS: Average follow-up was 8.4 years. High serum uric acid levels were associated with risk of myocardial infarction and stroke; age- and sex-adjusted hazard ratios (95% CIs) for highest versus lowest quintile of uric acid were 1.68 (1.24 to 2.27) for cardiovascular disease (515 cases), 1.87 (1.12 to 3.13) for myocardial infarction (194 cases), 1.57 (1.11 to 2.22) for stroke (381 cases), 1.77 (1.10 to 2.83) for ischemic stroke (205 cases), and 1.68 (0.68 to 4.15) for hemorrhagic stroke (46 cases). Adjustment for other vascular risk factors only slightly attenuated these associations. Associations were stronger in persons without hypertension than in those with hypertension. CONCLUSIONS: Uric acid is a strong risk factor for myocardial infarction and stroke.
BACKGROUND AND PURPOSE: The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke. Recent evidence suggests that uric acid may be an important causal agent in cardiovascular disease, for example, by inducing renal disease and hence hypertension. We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study. METHODS: The study was based on 4385 participants of the Rotterdam Study who, at baseline (1990 to 1993), were > or =55 years of age, free from stroke and coronary heart disease, and had blood taken. Follow-up for incident stroke and myocardial infarction was complete until January 1, 2002. Data were analyzed with Cox proportional hazards models with adjustment for relevant confounders. RESULTS: Average follow-up was 8.4 years. High serum uric acid levels were associated with risk of myocardial infarction and stroke; age- and sex-adjusted hazard ratios (95% CIs) for highest versus lowest quintile of uric acid were 1.68 (1.24 to 2.27) for cardiovascular disease (515 cases), 1.87 (1.12 to 3.13) for myocardial infarction (194 cases), 1.57 (1.11 to 2.22) for stroke (381 cases), 1.77 (1.10 to 2.83) for ischemic stroke (205 cases), and 1.68 (0.68 to 4.15) for hemorrhagic stroke (46 cases). Adjustment for other vascular risk factors only slightly attenuated these associations. Associations were stronger in persons without hypertension than in those with hypertension. CONCLUSIONS:Uric acid is a strong risk factor for myocardial infarction and stroke.
Authors: Stefan Walter; Johan Mackenbach; Zoltán Vokó; Stefan Lhachimi; M Arfan Ikram; André G Uitterlinden; Anne B Newman; Joanne M Murabito; Melissa E Garcia; Vilmundur Gudnason; Toshiko Tanaka; Gregory J Tranah; Henri Wallaschofski; Thomas Kocher; Lenore J Launer; Nora Franceschini; Maarten Schipper; Albert Hofman; Henning Tiemeier Journal: Am J Public Health Date: 2012-02-16 Impact factor: 9.308
Authors: Davide Grassi; Giovambattista Desideri; Anna Vittoria Di Giacomantonio; Paolo Di Giosia; Claudio Ferri Journal: High Blood Press Cardiovasc Prev Date: 2014-02-20
Authors: Gloria Brombo; Francesco Bonetti; Stefano Volpato; Mario L Morieri; Ettore Napoli; Stefania Bandinelli; Antonio Cherubini; Marcello Maggio; Jack Guralnik; Luigi Ferrucci; Giovanni Zuliani Journal: Nutr Metab Cardiovasc Dis Date: 2019-06-28 Impact factor: 4.222
Authors: M P Cruz-Domínguez; D H Montes-Cortes; I M Olivares-Corichi; O Vera-Lastra; G Medina; L J Jara Journal: Rheumatol Int Date: 2013-03-02 Impact factor: 2.631