BACKGROUND AND PURPOSE: Fractalkine receptor (CX3CR1) plays a key role during atherogenesis. CX3CR1 has 2 common coding polymorphisms, namely V249I and T280M, that have been associated with interindividual differences in susceptibility to atherosclerosis. In the present study, we investigated the possible association between CX3CR1variants and intima-media thickness (IMT). METHODS: We genotyped 1256 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study) for the presence of the V249 and the M280 variants of CX3CR1. RESULTS: Significantly reduced IMT was observed in subjects with the MM280 genotype (0.57+/-0.12 mm) compared with subjects with the TT (0.65+/-0.14 mm) or the TM (0.65+/-0.13 mm) genotype. No difference in IMT was observed within carrier of the II249, VI249, or VV249 genotype. Subjects with combined genotype VI249/MM280 and II249/MM280 showed a reduced IMT. CONCLUSIONS: The presence of the M280 polymorphism of the fractalkine receptor is associated with a decreased common carotid artery IMT, whereas the presence of the I249 polymorphism does not play a major role on the progression of carotid atherosclerosis.
BACKGROUND AND PURPOSE:Fractalkine receptor (CX3CR1) plays a key role during atherogenesis. CX3CR1 has 2 common coding polymorphisms, namely V249I and T280M, that have been associated with interindividual differences in susceptibility to atherosclerosis. In the present study, we investigated the possible association between CX3CR1variants and intima-media thickness (IMT). METHODS: We genotyped 1256 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study) for the presence of the V249 and the M280 variants of CX3CR1. RESULTS: Significantly reduced IMT was observed in subjects with the MM280 genotype (0.57+/-0.12 mm) compared with subjects with the TT (0.65+/-0.14 mm) or the TM (0.65+/-0.13 mm) genotype. No difference in IMT was observed within carrier of the II249, VI249, or VV249 genotype. Subjects with combined genotype VI249/MM280 and II249/MM280 showed a reduced IMT. CONCLUSIONS: The presence of the M280 polymorphism of the fractalkine receptor is associated with a decreased common carotid artery IMT, whereas the presence of the I249 polymorphism does not play a major role on the progression of carotid atherosclerosis.
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Authors: Andrea Romagnani; Elsa Rottoli; Emilia Maria Cristina Mazza; Tanja Rezzonico-Jost; Benedetta De Ponte Conti; Michele Proietti; Michela Perotti; Elisa Civanelli; Lisa Perruzza; Alberico L Catapano; Andrea Baragetti; Elena Tenedini; Enrico Tagliafico; Simonetta Falzoni; Francesco Di Virgilio; Giuseppe Danilo Norata; Silvio Bicciato; Fabio Grassi Journal: Cancer Res Date: 2020-07-22 Impact factor: 12.701
Authors: Seda Turkoglu Babakurban; Selim S Erbek; Yunus Kasim Terzi; Fatih Arslan; Feride I Sahin Journal: Eur Arch Otorhinolaryngol Date: 2014-02-05 Impact factor: 2.503
Authors: Matthias W Lorenz; Jackie F Price; Christine Robertson; Michiel L Bots; Joseph F Polak; Holger Poppert; Maryam Kavousi; Marcus Dörr; Eva Stensland; Pierre Ducimetiere; Kimmo Ronkainen; Stefan Kiechl; Matthias Sitzer; Tatjana Rundek; Lars Lind; Jing Liu; Göran Bergström; Liliana Grigore; Lena Bokemark; Alfonsa Friera; David Yanez; Horst Bickel; M Arfan Ikram; Henry Völzke; Stein Harald Johnsen; Jean Philippe Empana; Tomi-Pekka Tuomainen; Peter Willeit; Helmuth Steinmetz; Moise Desvarieux; Wuxiang Xie; Caroline Schmidt; Giuseppe D Norata; Carmen Suarez; Dirk Sander; Albert Hofman; Ulf Schminke; Ellisiv Mathiesen; Matthieu Plichart; Jussi Kauhanen; Johann Willeit; Ralph L Sacco; Stela McLachlan; Dong Zhao; Björn Fagerberg; Alberico L Catapano; Rafael Gabriel; Oscar H Franco; Alpaslan Bülbül; Frank Scheckenbach; Anja Pflug; Lu Gao; Simon G Thompson Journal: Diabetes Care Date: 2015-07-15 Impact factor: 19.112