| Literature DB >> 16675213 |
Hilary J Goldberg1, Douglas Fiedler, Amy Webb, Jashiree Jagirdar, Anastacio M Hoyumpa, Jay Peters.
Abstract
Recombinant interferon-alpha (rINF-alpha) is an immunomodulator used in the treatment of various conditions, including viral infections and malignancies. The use of rINF-alpha has been associated with the development of sarcoidosis in recent case reports. In this series, we report the incidence of sarcoidosis in recipients of rINF-alpha for hepatitis C viral (HCV) infection at our institution. We also review the 57 additional cases of sarcoidosis associated with rINF-alpha described in the literature, including clinical presentation, radiographic findings, management, and outcomes, and discuss the potential mechanisms by which rINF-alpha may lead to the development of sarcoidosis.Entities:
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Year: 2006 PMID： 16675213 DOI： 10.1016/j.rmed.2006.03.004
Source DB: PubMed Journal: Respir Med ISSN： 0954-6111 Impact factor: 3.415