Literature DB >> 16675065

Synthesis and antiproliferative activities of indolin-2-one derivatives bearing amino acid moieties.

Mathieu Sassatelli1, Eric Debiton, Bettina Aboab, Michelle Prudhomme, Pascale Moreau.   

Abstract

A convenient synthesis of indolin-2-ones substituted in the 3 position by an aminomethylene group bearing different amino acid moieties is described. Their antiproliferative activities were evaluated toward a panel of human solid tumor cell lines (PC 3, DLD-1, MCF-7, M4 Beu, A549, PA 1) and healthy cell lines (a murine fibroblast L929 and a human fibroblast primary culture).

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Year:  2006        PMID： 16675065     DOI： 10.1016/j.ejmech.2006.03.021

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

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3.  B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest.

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6.  Visible-Light-Mediated Dearomatisation of Indoles and Pyrroles to Pharmaceuticals and Pesticides.

Authors:  Waldemar Schilling; Yu Zhang; Daniel Riemer; Shoubhik Das
Journal:  Chemistry       Date:  2019-12-05       Impact factor: 5.236

7.  Direct alkenylation of indolin-2-ones by 6-aryl-4-methylthio-2H-pyran-2-one-3-carbonitriles: a novel approach.

Authors:  Sandeep Kumar; Ramendra Pratap; Abhinav Kumar; Brijesh Kumar; Vishnu K Tandon; Vishnu Ji Ram
Journal:  Beilstein J Org Chem       Date:  2013-04-25       Impact factor: 2.883
  7 in total

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