Literature DB >> 1667385

Decreased density and sensitivity of alpha 2-adrenoceptors in the brain of spontaneously hypertensive rats.

G Olmos1, A Miralles, F Barturen, J A García-Sevilla.   

Abstract

The specific binding of the agonist [corrected], [3H]clonidine, to neural membranes and clonidine-induced mydriasis were used to evaluate the density and sensitivity [corrected] of alpha 2-adrenoceptors in the brain of spontaneously hypertensive rats (SHR) and sex- and age-matched normotensive Wistar-Kyoto (WKY) rats. In hypertensive rats (SHR) the density of alpha 2-adrenoceptors was reduced in the cerebral cortex, hypothalamus and medulla oblongata (20-27%), as was the dose-pupillary response curve for clonidine (1.8-fold). The results demonstrated that this model of genetic hypertension is associated with desensitization of alpha 2-adrenoceptors in the brain.

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Year:  1991        PMID： 1667385     DOI： 10.1016/0014-2999(91)90776-m

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

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  6 in total

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