Literature DB >> 1667284

Differential actions of platelet-activating factor (PAF) receptor antagonists on the vasodilator and vasoconstrictor effects of PAF in the rat perfused heart.

W M Hu1, R Y Man.   

Abstract

Selectivity for blocking the coronary vasodilator and vasoconstrictor effects of platelet-activating factor (PAF) in the rat perfused heart was observed with different PAF antagonists. CV-6209 showed selectivity for blocking the vasodilator effect of PAF and a higher concentration (10 fold) was required to block the vasoconstrictor effect. The remaining PAF antagonists (FR-900452, WEB 2086 and BN-50739) showed selectivity for blocking the vasoconstrictor effect of PAF (10, 200 and 1000 fold respectively). A combination of low concentrations of CV-6209 (10 nM) with FR-900452 (5 microM) or WEB 2086 (0.5 microM) was effective in blocking both the vasodilator and vasoconstrictor effects of PAF. CV-6209 and WEB 2086 did not affect the vasodilator action of leukotriene B4 (LTB4) and the vasoconstrictor action of LTC4 and LTD4. Our results support the hypothesis that the functionally opposite effects of PAF in the rat perfused heart may be mediated by different PAF receptor subtypes.

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Year:  1991        PMID： 1667284      PMCID： PMC1908823          DOI： 10.1111/j.1476-5381.1991.tb12504.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4.

Authors:  P J Piper; A G Stewart
Journal:  Br J Pharmacol       Date:  1986-07       Impact factor: 8.739

Review 2.  Perspectives in platelet-activating factor research.

Authors:  P Braquet; L Touqui; T Y Shen; B B Vargaftig
Journal:  Pharmacol Rev       Date:  1987-06       Impact factor: 25.468

3.  Kadsurenone distinguishes between different platelet activating factor receptor subtypes on macrophages and polymorphonuclear leucocytes.

Authors:  G Lambrecht; M J Parnham
Journal:  Br J Pharmacol       Date:  1986-02       Impact factor: 8.739

4.  Characterization of platelet-activating factor (PAF) receptor by specific binding of [3H]L-659,989, a PAF receptor antagonist, to rabbit platelet membranes: possible multiple conformational states of a single type of PAF receptors.

Authors:  S B Hwang; M H Lam; A H Hsu
Journal:  Mol Pharmacol       Date:  1989-01       Impact factor: 4.436

5.  Coronary vascular response to platelet-activating factor in the perfused rat heart.

Authors:  R Y Man; W Hu; A A Kinnaird
Journal:  J Lipid Mediat       Date:  1990 Mar-Apr

6.  Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils.

Authors:  C Kroegel; T Yukawa; J Westwick; P J Barnes
Journal:  Biochem Biophys Res Commun       Date:  1989-07-14       Impact factor: 3.575

7.  Mechanisms of the coronary vascular effects of platelet-activating factor in the rat perfused heart.

Authors:  W Hu; A A Kinnaird; R Y Man
Journal:  Br J Pharmacol       Date:  1991-05       Impact factor: 8.739

8.  Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages.

Authors:  A G Stewart; G J Dusting
Journal:  Br J Pharmacol       Date:  1988-08       Impact factor: 8.739

9.  Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes.

Authors:  S B Hwang
Journal:  J Biol Chem       Date:  1988-03-05       Impact factor: 5.157
  9 in total
  6 in total

Review 1.  Structural and (patho)physiological diversity of PAF.

Authors:  R N Pinckard; D S Woodard; H J Showell; M J Conklyn; M J Novak; L M McManus
Journal:  Clin Rev Allergy       Date:  1994

2.  Nitric oxide (NO) modulation of PAF-induced cardiopulmonary action: interaction between NO synthase and cyclo-oxygenase-2 pathways.

Authors:  F Fabi; R Calabrese; T Stati; P del Basso
Journal:  Br J Pharmacol       Date:  2001-10       Impact factor: 8.739

3.  Similar coronary vascular effects in the rat perfused heart of platelet-activating factor structural analogues with agonist and antagonist properties.

Authors:  R Y Man; A A Kinnaird
Journal:  Br J Pharmacol       Date:  1995-11       Impact factor: 8.739

4.  Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism.

Authors:  Kathryn E Baker; Michael J Curtis
Journal:  Br J Pharmacol       Date:  2004-04-05       Impact factor: 8.739

5.  Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart.

Authors:  W Hu; I K McNicholl; P C Choy; R Y Man
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

Review 6.  Cardiotoxicity during invasive pneumococcal disease.

Authors:  Armand O Brown; Elizabeth R C Millett; Jennifer K Quint; Carlos J Orihuela
Journal:  Am J Respir Crit Care Med       Date:  2015-04-01       Impact factor: 21.405
  6 in total

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