Literature DB >> 16672686

Chronic addiction to dextromethorphan cough syrup: a case report.

Saili Desai1, Diana Aldea, Elisabeth Daneels, Manal Soliman, Amy S Braksmajer, Colin P Kopes-Kerr.   

Abstract

BACKGROUND: Serious drug abuse and addiction related to dextromethorphan-containing cough preparations has been a problem in the United States since the 1950s, but few physicians are aware of it. Physicians must be alert to the type of substances and quantities used and misused by patients in obtaining a thorough routine history of over-the-counter medication use.
METHODS: We describe the case of a 66-year-old clerical worker who ingested 4 to 16 oz of dextromethorphan on a regular basis over an 8-year period. We consulted with our local Poison Control Center and undertook a literature search to research previous reports of similar cases to identify the features that would aid physicians in recognition and management of this problem. RESULTS AND
CONCLUSION: Despite the availability of a substantial number of case reports in specialty journals, there are almost no reports in the primary care literature of chronic dextromethorphan addiction. Our case highlights the difficulties in making an appropriate diagnosis and in obtaining effective help for the patient.

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Year:  2006        PMID: 16672686     DOI: 10.3122/jabfm.19.3.320

Source DB:  PubMed          Journal:  J Am Board Fam Med        ISSN: 1557-2625            Impact factor:   2.657


  4 in total

1.  Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats.

Authors:  Kai Ting Po; Andrew Man-Hong Siu; Benson Wui-Man Lau; Jackie Ngai-Man Chan; Kwok-Fai So; Chetwyn C H Chan
Journal:  Exp Brain Res       Date:  2015-05-05       Impact factor: 1.972

Review 2.  Neuropsychopharmacological understanding for therapeutic application of morphinans.

Authors:  Eun-Joo Shin; Jau-Shyong Hong; Hyoung-Chun Kim
Journal:  Arch Pharm Res       Date:  2010-10-30       Impact factor: 4.946

3.  PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT1A Receptor and Upregulation of Nrf2-Dependent GSH Synthesis.

Authors:  Hai-Quyen Tran; Youngho Lee; Eun-Joo Shin; Choon-Gon Jang; Ji Hoon Jeong; Akihiro Mouri; Kuniaki Saito; Toshitaka Nabeshima; Hyoung-Chun Kim
Journal:  Mol Neurobiol       Date:  2018-02-22       Impact factor: 5.590

4.  Alterations in the biochemical indices in Wistar rats exposed to an overdose of codeine and dextromethorphan.

Authors:  Abolanle A Kayode; Omowumi T Kayode; Opemipo J Oridota
Journal:  J Taibah Univ Med Sci       Date:  2021-01-28
  4 in total

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