Literature DB >> 16672627

Helicobacter pylori initiates the stringent response upon nutrient and pH downshift.

Derek H Wells1, Erin C Gaynor.   

Abstract

Helicobacter pylori was previously reported to lack a stringent response. In contrast, we show that after nutrient downshift, H. pylori produced abundant ppGpp and less total RNA. pH downshift also caused (p)ppGpp accumulation. Our observations indicate that nutrient deprivation and acid shock activate the stringent response in H. pylori.

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Year:  2006        PMID： 16672627      PMCID： PMC1482847          DOI： 10.1128/JB.188.10.3726-3729.2006

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  24 in total

1.  Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations.

Authors:  H Xiao; M Kalman; K Ikehara; S Zemel; G Glaser; M Cashel
Journal:  J Biol Chem       Date:  1991-03-25       Impact factor: 5.157

2.  Cloning and characterization of a relA/spoT homologue from Bacillus subtilis.

Authors:  T M Wendrich; M A Marahiel
Journal:  Mol Microbiol       Date:  1997-10       Impact factor: 3.501

3.  The control of ribonucleic acid synthesis in Escherichia coli. IV. Relevance of unusual phosphorylated compounds from amino acid-starved stringent strains.

Authors:  M Cashel
Journal:  J Biol Chem       Date:  1969-06-25       Impact factor: 5.157

4.  The Campylobacter jejuni stringent response controls specific stress survival and virulence-associated phenotypes.

Authors:  Erin C Gaynor; Derek H Wells; Joanna K MacKichan; Stanley Falkow
Journal:  Mol Microbiol       Date:  2005-04       Impact factor: 3.501

5.  Co-ordination of legionella pneumophila virulence with entry into stationary phase by ppGpp.

Authors:  B K Hammer; M S Swanson
Journal:  Mol Microbiol       Date:  1999-08       Impact factor: 3.501

Review 6.  Helicobacter pylori physiology predicted from genomic comparison of two strains.

Authors:  P Doig; B L de Jonge; R A Alm; E D Brown; M Uria-Nickelsen; B Noonan; S D Mills; P Tummino; G Carmel; B C Guild; D T Moir; G F Vovis; T J Trust
Journal:  Microbiol Mol Biol Rev       Date:  1999-09       Impact factor: 11.056

7.  Iron limitation induces SpoT-dependent accumulation of ppGpp in Escherichia coli.

Authors:  Daniel Vinella; Christian Albrecht; Michael Cashel; Richard D'Ari
Journal:  Mol Microbiol       Date:  2005-05       Impact factor: 3.501

Review 8.  Helicobacter pylori VacA, a paradigm for toxin multifunctionality.

Authors:  Timothy L Cover; Steven R Blanke
Journal:  Nat Rev Microbiol       Date:  2005-04       Impact factor: 60.633

9.  Helicobacter pylori: a eubacterium lacking the stringent response.

Authors:  G L Scoarughi; C Cimmino; P Donini
Journal:  J Bacteriol       Date:  1999-01       Impact factor: 3.490

10.  Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.

Authors:  R A Alm; L S Ling; D T Moir; B L King; E D Brown; P C Doig; D R Smith; B Noonan; B C Guild; B L deJonge; G Carmel; P J Tummino; A Caruso; M Uria-Nickelsen; D M Mills; C Ives; R Gibson; D Merberg; S D Mills; Q Jiang; D E Taylor; G F Vovis; T J Trust
Journal:  Nature       Date:  1999-01-14       Impact factor: 49.962
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  31 in total

Review 1.  ppGpp conjures bacterial virulence.

Authors:  Zachary D Dalebroux; Sarah L Svensson; Erin C Gaynor; Michele S Swanson
Journal:  Microbiol Mol Biol Rev       Date:  2010-06       Impact factor: 11.056

Review 2.  (p)ppGpp and Its Role in Bacterial Persistence: New Challenges.

Authors:  Olga Pacios; Lucia Blasco; Inés Bleriot; Laura Fernandez-Garcia; Antón Ambroa; María López; German Bou; Rafael Cantón; Rodolfo Garcia-Contreras; Thomas K Wood; Maria Tomás
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

3.  Whole-genome sequencing reveals a link between β-lactam resistance and synthetases of the alarmone (p)ppGpp in Staphylococcus aureus.

Authors:  Michael M Mwangi; Choonkeun Kim; Marilyn Chung; Jennifer Tsai; Govindan Vijayadamodar; Michelle Benitez; Thomas P Jarvie; Lei Du; Alexander Tomasz
Journal:  Microb Drug Resist       Date:  2013-05-09       Impact factor: 3.431

Review 4.  Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments.

Authors:  R Trastoy; T Manso; L Fernández-García; L Blasco; A Ambroa; M L Pérez Del Molino; G Bou; R García-Contreras; T K Wood; M Tomás
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

5.  Overexpression of spoT gene in coccoid forms of clinical Helicobacter pylori isolates.

Authors:  Farkhondeh Poursina; Jamshid Fagri; Nasrin Mirzaei; Hajieh Ghasemian Safaei
Journal:  Folia Microbiol (Praha)       Date:  2018-01-11       Impact factor: 2.099

6.  The stringent response is required for Helicobacter pylori survival of stationary phase, exposure to acid, and aerobic shock.

Authors:  Kyle Mouery; Bethany A Rader; Erin C Gaynor; Karen Guillemin
Journal:  J Bacteriol       Date:  2006-08       Impact factor: 3.490

7.  Polyphosphate binds to the principal sigma factor of RNA polymerase during starvation response in Helicobacter pylori.

Authors:  Zhao Xu Yang; Yan Ning Zhou; Yi Yang; Ding Jun Jin
Journal:  Mol Microbiol       Date:  2010-06-11       Impact factor: 3.501

8.  Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori.

Authors:  Yan Ning Zhou; William G Coleman; Zhaoxu Yang; Yi Yang; Nathaniel Hodgson; Fuxiang Chen; Ding Jun Jin
Journal:  J Bacteriol       Date:  2008-10-03       Impact factor: 3.490

9.  ppGpp metabolism is involved in heterocyst development in the cyanobacterium Anabaena sp. strain PCC 7120.

Authors:  Shao-Ran Zhang; Gui-Ming Lin; Wen-Li Chen; Li Wang; Cheng-Cai Zhang
Journal:  J Bacteriol       Date:  2013-08-09       Impact factor: 3.490

10.  SpoT-triggered stringent response controls usp gene expression in Pseudomonas aeruginosa.

Authors:  Nelli Boes; Kerstin Schreiber; Max Schobert
Journal:  J Bacteriol       Date:  2008-09-05       Impact factor: 3.490
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