| Literature DB >> 16672429 |
Anne-Christine Jouvencel1, Didier Neau, Muriel Faure, Martine Neau, Christophe Martinaud, Elisabeth Legrand, Pascale Trimoulet, Isabelle Garrigue, Brigitte Le Bail, Paulette Bioulac-Sage, Michel Dupon, Jean-Marie Ragnaud, Herve Fleury, Marie-Edith Lafon.
Abstract
Liver and plasma hepatitis C virus (HCV) variability was compared by E2 cloning and sequencing in three patients coinfected with HCV and human immunodeficiency virus (HIV) before and after interferon treatment and in three patients solely infected with HCV. The plasma and liver samples contained unique sequences. In the patients coinfected with HIV, accumulated random mutations produced mostly nonsynonymous substitutions in contrast to the reduced HCV genetic variability seen after treatment.Entities:
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Year: 2006 PMID： 16672429 PMCID： PMC1479191 DOI： 10.1128/JCM.44.5.1877-1880.2006
Source DB: PubMed Journal: J Clin Microbiol ISSN： 0095-1137 Impact factor: 5.948