Literature DB >> 16672419

Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.

Juergen Loeffler1, Michael Steffens, Eva-Maria Arlt, Mohammad-Reza Toliat, Markus Mezger, Anita Suk, Thomas F Wienker, Holger Hebart, Peter Nürnberg, Michael Boeckh, Per Ljungman, Rudolf Trenschel, Hermann Einsele.   

Abstract

We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

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Year:  2006        PMID: 16672419      PMCID: PMC1479205          DOI: 10.1128/JCM.44.5.1847-1850.2006

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN: 0095-1137            Impact factor:   5.948


  18 in total

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