| Literature DB >> 16672419 |
Juergen Loeffler1, Michael Steffens, Eva-Maria Arlt, Mohammad-Reza Toliat, Markus Mezger, Anita Suk, Thomas F Wienker, Holger Hebart, Peter Nürnberg, Michael Boeckh, Per Ljungman, Rudolf Trenschel, Hermann Einsele.
Abstract
We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.Entities:
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Year: 2006 PMID: 16672419 PMCID: PMC1479205 DOI: 10.1128/JCM.44.5.1847-1850.2006
Source DB: PubMed Journal: J Clin Microbiol ISSN: 0095-1137 Impact factor: 5.948