BACKGROUND: Periodontitis has been associated with increased risk of adverse pregnancy outcomes and elevated C-reactive protein (CRP) concentrations in non-pregnant adults. We examined the relationship between periodontitis and CRP among women who provided dental radiographs and had blood collected during early pregnancy, excluding smokers and diabetic patients. METHODS: From Project Viva, an ongoing cohort study, we measured plasma CRP in 35 subjects with periodontitis (i.e., at least one site with > or =3 mm of alveolar bone loss) and a random sample of 66 periodontally healthy subjects matched on age and race/ethnicity. We performed linear regression analysis with log-transformed CRP levels as the outcome. RESULTS: The mean (+/- SE) CRP level was 65% higher (95% confidence interval: -2%, 180%; P = 0.06) in women with periodontitis (2.46 +/- 0.52 mg/l) than in controls (1.49 +/- 0.22 mg/l), adjusting for factors related to CRP levels, including age, race/ethnicity, pre-pregnancy body mass index, alcohol intake, education, income, and gestational age at blood collection. CONCLUSIONS: These findings suggest that periodontitis may increase CRP levels in pregnancy. CRP could potentially mediate the association of periodontitis with adverse pregnancy outcomes.
BACKGROUND:Periodontitis has been associated with increased risk of adverse pregnancy outcomes and elevated C-reactive protein (CRP) concentrations in non-pregnant adults. We examined the relationship between periodontitis and CRP among women who provided dental radiographs and had blood collected during early pregnancy, excluding smokers and diabeticpatients. METHODS: From Project Viva, an ongoing cohort study, we measured plasma CRP in 35 subjects with periodontitis (i.e., at least one site with > or =3 mm of alveolar bone loss) and a random sample of 66 periodontally healthy subjects matched on age and race/ethnicity. We performed linear regression analysis with log-transformed CRP levels as the outcome. RESULTS: The mean (+/- SE) CRP level was 65% higher (95% confidence interval: -2%, 180%; P = 0.06) in women with periodontitis (2.46 +/- 0.52 mg/l) than in controls (1.49 +/- 0.22 mg/l), adjusting for factors related to CRP levels, including age, race/ethnicity, pre-pregnancy body mass index, alcohol intake, education, income, and gestational age at blood collection. CONCLUSIONS: These findings suggest that periodontitis may increase CRP levels in pregnancy. CRP could potentially mediate the association of periodontitis with adverse pregnancy outcomes.
Authors: Margit Fröhlich; Malte Sund; Barbara Thorand; Winston L Hutchinson; Mark B Pepys; Wolfgang Koenig Journal: Clin Chem Date: 2002-03 Impact factor: 8.327
Authors: K S Kornman; A Crane; H Y Wang; F S di Giovine; M G Newman; F W Pirk; T G Wilson; F L Higginbottom; G W Duff Journal: J Clin Periodontol Date: 1997-01 Impact factor: 8.728
Authors: Peter Berger; Joseph P McConnell; Martha Nunn; Kenneth S Kornman; Julian Sorrell; Katherine Stephenson; Gordon W Duff Journal: Cytokine Date: 2002-02-21 Impact factor: 3.861
Authors: Amanda L Horton; Kim A Boggess; Kevin L Moss; Heather L Jared; James Beck; Steven Offenbacher Journal: J Periodontol Date: 2008-07 Impact factor: 6.993