Literature DB >> 16671124

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone.

Maria Chiara Monti1, Agostino Casapullo, Cosima Santomauro, Maria Valeria D'Auria, Raffaele Riccio, Luigi Gomez-Paloma.   

Abstract

The molecular basis of the inactivation of bee venom PLA2 by the marine natural product bolinaquinone (BLQ) was studied by several spectral techniques (CD, fluorescence, and NMR spectroscopy, mass spectrometry), biomimetic reactions, and molecular modeling. Our data suggest competitive inhibition based on a BLQ-PLA2 noncovalent molecular recognition. However, BLQ is also able to react selectively with Lys133 through conjugate addition followed by a beta elimination. The biological implications of both the covalent and noncovalent molecular events are discussed.

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Year:  2006        PMID： 16671124     DOI： 10.1002/cbic.200500454

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  5 in total

1.  Phospholipase A2 inhibits cisplatin-induced acute kidney injury by modulating regulatory T cells by the CD206 mannose receptor.

Authors:  Hyunseong Kim; Hyojung Lee; Gihyun Lee; Hyunil Jang; Sung-Su Kim; Heera Yoon; Geun-Hyung Kang; Deok-Sang Hwang; Sun Kwang Kim; Hwan-Suck Chung; Hyunsu Bae
Journal:  Kidney Int       Date:  2015-05-20       Impact factor: 10.612

2.  Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain.

Authors:  Dongxing Li; Younju Lee; Woojin Kim; Kyungjin Lee; Hyunsu Bae; Sun Kwang Kim
Journal:  Toxins (Basel)       Date:  2015-06-29       Impact factor: 4.546

3.  Bee venom phospholipase A2 protects against acetaminophen-induced acute liver injury by modulating regulatory T cells and IL-10 in mice.

Authors:  Hyunseong Kim; Dong June Keum; Jung won Kwak; Hwan-Suck Chung; Hyunsu Bae
Journal:  PLoS One       Date:  2014-12-05       Impact factor: 3.240

Review 4.  The protective effect of bee venom on fibrosis causing inflammatory diseases.

Authors:  Woo-Ram Lee; Sok Cheon Pak; Kwan-Kyu Park
Journal:  Toxins (Basel)       Date:  2015-11-16       Impact factor: 4.546

5.  Preventive Effects of Bee Venom Derived Phospholipase A₂ on Oxaliplatin-Induced Neuropathic Pain in Mice.

Authors:  Dongxing Li; Woojin Kim; Dasom Shin; Yongjae Jung; Hyunsu Bae; Sun Kwang Kim
Journal:  Toxins (Basel)       Date:  2016-01-19       Impact factor: 4.546
  5 in total

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