OBJECTIVES: To investigate the effect of treatment with several vasodilatory substance on the changes in mean arterial pressure (MAP) of severe acute pancreatitis. METHODS: Pancreatitis was induced in rats by 5% sodium taurocholate retrograde infusion through the pancreatic duct, which produces a significant decrease in arterial blood pressure. RESULTS: Three hours after the induction of pancreatitis, a fall of approximately 25 mm Hg in MAP was observed, with no changes of MAP in untreated controls. The administration of the nitric oxide synthesis inhibitor, N-nitro-L-arginine methyl ester (25 mg/kg), previously to the induction of pancreatitis, produced a marked fall in MAP leading to the death of all the animals. When several vasodilatory substances, S-nitroso-N-acetylpenicillamine (200 microg x kg x h), calcitonin gene-related peptide (10 microg/kg), and vasoactive intestinal polypeptide (8 microg x kg x h) were administered previously to the induction of pancreatitis, the MAP fall induced by pancreatitis was not observed. The improvement of physiological conditions observed in vasodilator-treated animals is in agreement with histological data, which show only minor structural changes in the pancreas from these animals, in contrast with the severe alterations observed in untreated pancreatitic rats. CONCLUSION: : Vasodilation confers protection against the systemic circulatory derangement derived from the development of severe acute pancreatitis.
OBJECTIVES: To investigate the effect of treatment with several vasodilatory substance on the changes in mean arterial pressure (MAP) of severe acute pancreatitis. METHODS:Pancreatitis was induced in rats by 5% sodium taurocholate retrograde infusion through the pancreatic duct, which produces a significant decrease in arterial blood pressure. RESULTS: Three hours after the induction of pancreatitis, a fall of approximately 25 mm Hg in MAP was observed, with no changes of MAP in untreated controls. The administration of the nitric oxide synthesis inhibitor, N-nitro-L-arginine methyl ester (25 mg/kg), previously to the induction of pancreatitis, produced a marked fall in MAP leading to the death of all the animals. When several vasodilatory substances, S-nitroso-N-acetylpenicillamine (200 microg x kg x h), calcitonin gene-related peptide (10 microg/kg), and vasoactive intestinal polypeptide (8 microg x kg x h) were administered previously to the induction of pancreatitis, the MAP fall induced by pancreatitis was not observed. The improvement of physiological conditions observed in vasodilator-treated animals is in agreement with histological data, which show only minor structural changes in the pancreas from these animals, in contrast with the severe alterations observed in untreated pancreatitic rats. CONCLUSION: : Vasodilation confers protection against the systemic circulatory derangement derived from the development of severe acute pancreatitis.
Authors: Mónica García; Ernesto Hernández Barbáchano; Pilar Hernández Lorenzo; José Ignacio San Román; María A López; Rafael Coveñas; José Julián Calvo Journal: Dig Dis Sci Date: 2008-07-04 Impact factor: 3.199
Authors: Joanna Bonior; Zygmunt Warzecha; Piotr Ceranowicz; Ryszard Gajdosz; Piotr Pierzchalski; Michalina Kot; Anna Leja-Szpak; Katarzyna Nawrot-Porąbka; Paweł Link-Lenczowski; Michał Pędziwiatr; Rafał Olszanecki; Krzysztof Bartuś; Rafał Trąbka; Beata Kuśnierz-Cabala; Artur Dembiński; Jolanta Jaworek Journal: Int J Mol Sci Date: 2017-06-30 Impact factor: 5.923
Authors: Jakub Bukowczan; Zygmunt Warzecha; Piotr Ceranowicz; Beata Kuśnierz-Cabala; Romana Tomaszewska Journal: PLoS One Date: 2015-07-30 Impact factor: 3.240
Authors: Zygmunt Warzecha; Paweł Sendur; Piotr Ceranowicz; Marcin Dembiński; Jakub Cieszkowski; Beata Kuśnierz-Cabala; Rafał Olszanecki; Romana Tomaszewska; Tadeusz Ambroży; Artur Dembiński Journal: Int J Mol Sci Date: 2016-10-12 Impact factor: 5.923
Authors: Zygmunt Warzecha; Paweł Sendur; Piotr Ceranowicz; Jakub Cieszkowski; Marcin Dembiński; Ryszard Sendur; Joanna Bonior; Jolanta Jaworek; Tadeusz Ambroży; Rafał Olszanecki; Beata Kuśnierz-Cabala; Kaczmarzyk Tomasz; Romana Tomaszewska; Artur Dembiński Journal: Int J Mol Sci Date: 2017-04-21 Impact factor: 5.923