N M Elsharnouby1, M M Elsharnouby. 1. Department of Anesthesiology and Intensive Care, Faculty of Medicine, Ain-shams University, Cairo, Egypt. nmelsharhnouby@hotmail.com
Abstract
BACKGROUND: This randomized, double-blind, placebo-controlled study was designed to assess the effect of perioperatively administered i.v. magnesium sulphate as a technique of hypotensive anaesthesia. METHODS:Sixty patients (25 female) undergoing functional endoscopic sinus surgery were included in two parallel groups. The magnesium group received magnesium sulphate 40 mg kg(-1) i.v. as a bolus before induction of anaesthesia and 15 mg kg(-1) h(-1) by continuous i.v. infusion during the operation. The same volume of isotonic solution was administered to the control group. Intraoperative bleeding was evaluated using a quality scale. RESULTS: In the magnesium group, there was a reduction in surgical time [68.1 (15.6) min vs 88.1 (10.7) min], although the anaesthetic time was 10 min longer and thus presuming a prolongation in anaesthetic emergence. There was a significant reduction of blood loss [165 (19) ml vs 257 (21) ml]. The anaesthetic requirements (fentanyl, vercuronium and sevoflurane), mean arterial blood pressure (P<0.005) and heart rate (P<0.005) were also significantly reduced. CONCLUSION:Magnesium sulphate led to a reduction in arterial pressure, heart rate, blood loss and duration of surgery. Furthermore, magnesium infusion alters anaesthetic dose requirements and emergence time.
RCT Entities:
BACKGROUND: This randomized, double-blind, placebo-controlled study was designed to assess the effect of perioperatively administered i.v. magnesium sulphate as a technique of hypotensive anaesthesia. METHODS: Sixty patients (25 female) undergoing functional endoscopic sinus surgery were included in two parallel groups. The magnesium group received magnesium sulphate 40 mg kg(-1) i.v. as a bolus before induction of anaesthesia and 15 mg kg(-1) h(-1) by continuous i.v. infusion during the operation. The same volume of isotonic solution was administered to the control group. Intraoperative bleeding was evaluated using a quality scale. RESULTS: In the magnesium group, there was a reduction in surgical time [68.1 (15.6) min vs 88.1 (10.7) min], although the anaesthetic time was 10 min longer and thus presuming a prolongation in anaesthetic emergence. There was a significant reduction of blood loss [165 (19) ml vs 257 (21) ml]. The anaesthetic requirements (fentanyl, vercuronium and sevoflurane), mean arterial blood pressure (P<0.005) and heart rate (P<0.005) were also significantly reduced. CONCLUSION:Magnesium sulphate led to a reduction in arterial pressure, heart rate, blood loss and duration of surgery. Furthermore, magnesium infusion alters anaesthetic dose requirements and emergence time.
Authors: Y Escamilla; A Cardesín; L Samara; S López; A Izquierdo; M Fradera; R Vives; M Bernal-Sprekelsen; Caridad Pontes Journal: Eur Arch Otorhinolaryngol Date: 2019-07-30 Impact factor: 2.503
Authors: David P Martin; Walter P Samora; Allan C Beebe; Jan Klamar; Laura Gill; Tarun Bhalla; Giorgio Veneziano; Arlyne Thung; Dmitry Tumin; N'Diris Barry; Julie Rice; Joseph D Tobias Journal: J Anesth Date: 2018-08-04 Impact factor: 2.078
Authors: Elizabeth A Kelly; Suneeta Gollapudy; Matthias L Riess; Harvey J Woehlck; Todd A Loehrl; David M Poetker Journal: Int Forum Allergy Rhinol Date: 2012-12-19 Impact factor: 3.858
Authors: Mohammad R Ghodraty; Mohammad M Homaee; Kourosh Farazmehr; Ali R Nikzad-Jamnani; Masoud Soleymani-Dodaran; Ali R Pournajafian; Nader D Nader Journal: World J Orthop Date: 2014-01-18