Literature DB >> 16669641

Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes.

Julie E Reed1, Anna Arola Arnal, Stephen Neidle, Ramón Vilar.   

Abstract

Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations.

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Year:  2006        PMID： 16669641     DOI： 10.1021/ja058509n

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  44 in total

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Authors:  Sabine A S Langie; Gudrun Koppen; Daniel Desaulniers; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Amaya Azqueta; William H Bisson; Dustin G Brown; Gunnar Brunborg; Amelia K Charles; Tao Chen; Annamaria Colacci; Firouz Darroudi; Stefano Forte; Laetitia Gonzalez; Roslida A Hamid; Lisbeth E Knudsen; Luc Leyns; Adela Lopez de Cerain Salsamendi; Lorenzo Memeo; Chiara Mondello; Carmel Mothersill; Ann-Karin Olsen; Sofia Pavanello; Jayadev Raju; Emilio Rojas; Rabindra Roy; Elizabeth P Ryan; Patricia Ostrosky-Wegman; Hosni K Salem; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Frederik J Van Schooten; Mahara Valverde; Jordan Woodrick; Luoping Zhang; Nik van Larebeke; Micheline Kirsch-Volders; Andrew R Collins
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

4.  Copper(ii) l/d-valine-(1,10-phen) complexes target human telomeric G-quadruplex motifs and promote site-specific DNA cleavage and cellular cytotoxicity.

Authors:  Farukh Arjmand; Surbhi Sharma; Sabiha Parveen; Loic Toupet; Zhen Yu; James Allan Cowan
Journal:  Dalton Trans       Date:  2020-07-21       Impact factor: 4.390

Review 5.  The effect of environmental chemicals on the tumor microenvironment.

Authors:  Stephanie C Casey; Monica Vaccari; Fahd Al-Mulla; Rabeah Al-Temaimi; Amedeo Amedei; Mary Helen Barcellos-Hoff; Dustin G Brown; Marion Chapellier; Joseph Christopher; Colleen S Curran; Stefano Forte; Roslida A Hamid; Petr Heneberg; Daniel C Koch; P K Krishnakumar; Ezio Laconi; Veronique Maguer-Satta; Fabio Marongiu; Lorenzo Memeo; Chiara Mondello; Jayadev Raju; Jesse Roman; Rabindra Roy; Elizabeth P Ryan; Sandra Ryeom; Hosni K Salem; A Ivana Scovassi; Neetu Singh; Laura Soucek; Louis Vermeulen; Jonathan R Whitfield; Jordan Woodrick; Annamaria Colacci; William H Bisson; Dean W Felsher
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

6.  Synthesis, characterization, and DNA binding of a novel ligand and its Cu (II) complex.

Authors:  Mei-Jin Li; Tao-Yu Lan; Zhi-Shan Lin; Changqing Yi; Guo-Nan Chen
Journal:  J Biol Inorg Chem       Date:  2013-12       Impact factor: 3.358

7.  Formation of a unique end-to-end stacked pair of G-quadruplexes in the hTERT core promoter with implications for inhibition of telomerase by G-quadruplex-interactive ligands.

Authors:  SunMi L Palumbo; Scot W Ebbinghaus; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2009-08-12       Impact factor: 15.419

8.  Anti-tumor activity and mechanism of apoptosis of A549 induced by ruthenium complex.

Authors:  Dongdong Sun; Zhipeng Mou; Nuan Li; Weiwei Zhang; Yazhe Wang; Endong Yang; Weiyun Wang
Journal:  J Biol Inorg Chem       Date:  2016-09-12       Impact factor: 3.358

9.  Interaction between cationic zinc porphyrin and lead ion induced telomeric guanine quadruplexes: evidence for end-stacking.

Authors:  Jingxi Pan; Suping Zhang
Journal:  J Biol Inorg Chem       Date:  2008-12-02       Impact factor: 3.358

10.  End-stacking of copper cationic porphyrins on parallel-stranded guanine quadruplexes.

Authors:  Sarah E Evans; Miguel A Mendez; Kevin B Turner; Loryn R Keating; Ryan T Grimes; Sarah Melchoir; Veronika A Szalai
Journal:  J Biol Inorg Chem       Date:  2007-09-05       Impact factor: 3.358
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