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Literature DB >> 16666081

Superoxide free radicals are produced in glyoxysomes.

L M Sandalio¹, V M Fernández, F L Rupérez, L A Del Río.

Abstract

The production of superoxide free radicals in pellet and supernatant fractions of glyoxysomes, specialized plant peroxisomes from watermelon (Citrullus vulgaris Schrad.) cotyledons, was investigated. Upon inhibition of the endogenous superoxide dismutase, xanthine, and hypoxanthine induced in glyoxysomal supernatants the generation of O(2) (-) radicals and this was inhibited by allopurinol. In glyoxysomal pellets, NADH stimulated the generation of superoxide radicals. Superoxide production by purines was due to xanthine oxidase, which was found predominantly in the matrix of glyoxysomes. The generation of O(2) (-) radicals in glyoxysomes by endogenous metabolites suggests new active oxygen-related roles for glyoxysomes, and for peroxisomes in general, in cellular metabolism.

Entities: Chemical Species

Year: 1988 PMID： 16666081 PMCID： PMC1054687 DOI： 10.1104/pp.87.1.1

Source DB: PubMed Journal: Plant Physiol ISSN： 0032-0889 Impact factor: 8.340

14 in total

1. Spin trapping of superoxide.

Authors: E Finkelstein; G M Rosen; E J Rauckman; J Paxton
Journal: Mol Pharmacol Date: 1979-09 Impact factor: 4.436

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

Review 3. Peroxisomal disorders: a newly recognised group of genetic diseases.

Authors: R B Schutgens; H S Heymans; R J Wanders; H van den Bosch; J M Tager
Journal: Eur J Pediatr Date: 1986-02 Impact factor: 3.183

Review 4. Superoxide dismutases.

Authors: I Fridovich
Journal: Adv Enzymol Relat Areas Mol Biol Date: 1986

5. Superoxide production by purified hamster hepatic nuclei.

Authors: S E Patton; G M Rosen; E J Rauckman
Journal: Mol Pharmacol Date: 1980-11 Impact factor: 4.436

6. Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.

Authors: A Boveris
Journal: Methods Enzymol Date: 1984 Impact factor: 1.600

7. Spin trapping of superoxide and hydroxyl radicals.

Authors: G M Rosen; E J Rauckman
Journal: Methods Enzymol Date: 1984 Impact factor: 1.600

8. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium.

Authors: E D Jarasch; C Grund; G Bruder; H W Heid; T W Keenan; W W Franke
Journal: Cell Date: 1981-07 Impact factor: 41.582

Review 9. Spin trapping of superoxide and hydroxyl radical: practical aspects.

Authors: E Finkelstein; G M Rosen; E J Rauckman
Journal: Arch Biochem Biophys Date: 1980-03 Impact factor: 4.013

10. Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

Authors: B E Britigan; G M Rosen; Y Chai; M S Cohen
Journal: J Biol Chem Date: 1986-04-05 Impact factor: 5.157

14 in total

1. Streptomyces coelicolor encodes a urate-responsive transcriptional regulator with homology to PecS from plant pathogens.

Authors: Hao Huang; Brian J Mackel; Anne Grove
Journal: J Bacteriol Date: 2013-08-30 Impact factor: 3.490

Review 2. Oxidative stress and living cells.

Authors: G Gille; K Sigler
Journal: Folia Microbiol (Praha) Date: 1995 Impact factor: 2.099

Superoxide free radicals are produced in glyoxysomes.

1. Spin trapping of superoxide.

2. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Review 3. Peroxisomal disorders: a newly recognised group of genetic diseases.

Review 4. Superoxide dismutases.

5. Superoxide production by purified hamster hepatic nuclei.

6. Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria.

7. Spin trapping of superoxide and hydroxyl radicals.

8. Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium.

Review 9. Spin trapping of superoxide and hydroxyl radical: practical aspects.

10. Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1. Streptomyces coelicolor encodes a urate-responsive transcriptional regulator with homology to PecS from plant pathogens.

Review 2. Oxidative stress and living cells.

Review 3. Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases.

4. Postanoxic Injury in Soybean (Glycine max) Seedlings.

5. NADH Induces the Generation of Superoxide Radicals in Leaf Peroxisomes.

Review 6. Cell biology of molybdenum in plants.

Review 7. Peroxisomes sense and respond to environmental cues by regulating ROS and RNS signalling networks.

Review 8. A new cellular function for peroxisomes related to oxygen free radicals?

9. The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination.

Review 10. A re-evaluation of the tissue distribution and physiology of xanthine oxidoreductase.