| Literature DB >> 166646 |
S L Spruance, O C Richards, C B Smith, J R Ward.
Abstract
Cultured synovial cells from 8 patients with rheumatoid arthritis (RA) and 7 subjects without joint disease were assayed and comapred for RNA-directed and DNA-directed DNA polymerase activity. No activity was found in either RA or control specimens using a synthetic RNA template that specificically detects oncornavirus RNA-directed DNA polymerase. The DNA-directed DNA polymerase activity of RA specimens was increased (P less than 0.10) in the high-speed pellet fraction of cell lysates. The possible relationship of these finding to virus infection in RA is disscussed.Entities:
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Year: 1975 PMID： 166646 DOI： 10.1002/art.1780180306
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591