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Literature DB >> 16662928

Inhibition of Glutamine Synthetase from Pea by Tabtoxinine-beta-lactam.

M D Thomas¹, P J Langston-Unkefer, T F Uchytil, R D Durbin.

Abstract

Tabtoxinine-beta-lactam, a hydrolytic product of tabtoxin produced by Pseudomonas syringae pv. tabaci, apparently inactivates pea seed glutamine synthetase. Inhibition of the enzyme's initial velocity is linear over a range of 0.5 to 5 millimolar tabtoxinine-beta-lactam in the presence of 10 millimolar glutamate. A method for the purification of glutamine synthetase from dried peas is presented which gives a 30% yield with a 2,000-fold increase in specific activity. A method for obtaining highly purified tabtoxinine-beta-lactam and tabtoxin in good yields is also presented. The authenticity and purity of tabtoxinine-beta-lactam and tabtoxin were verified by chromatography, biological activity, and (1)H and (13)C nuclear magnetic resonance spectroscopy.

Entities: Chemical Species

Year: 1983 PMID： 16662928 PMCID： PMC1066143 DOI： 10.1104/pp.71.4.912

Source DB: PubMed Journal: Plant Physiol ISSN： 0032-0889 Impact factor: 8.340

9 in total

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Authors: D W WOOLLEY; G SCHAFFNER; A C BRAUN
Journal: J Biol Chem Date: 1955-08 Impact factor: 5.157

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Authors: W H ELLIOTT
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Authors: J E Varner; G C Webster
Journal: Plant Physiol Date: 1955-09 Impact factor: 8.340

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Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

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Journal: Nature Date: 1971-01-15 Impact factor: 49.962

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Authors: P A Taylor; H K Schnoes; R D Durbin
Journal: Biochim Biophys Acta Date: 1972-11-24

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Authors: S L Sinden; R D Durbin
Journal: Nature Date: 1968-07-27 Impact factor: 49.962

8. Sources of ammonium in oat leaves treated with tabtoxin or methionine sulfoximine.

Authors: T A Frantz; D M Peterson; R D Durbin
Journal: Plant Physiol Date: 1982-02 Impact factor: 8.340

9. Reactivation of glutamine synthetase from Escherichia coli after auto-inactivation with L-methionine-S-sulfoximine, ATP, and Mn2+.

Authors: M R Maurizi; A Ginsburg
Journal: J Biol Chem Date: 1982-04-25 Impact factor: 5.157

9 in total

22 in total

1. Cloning and expression of the tabtoxin biosynthetic region from Pseudomonas syringae.

Authors: T G Kinscherf; R H Coleman; T M Barta; D K Willis
Journal: J Bacteriol Date: 1991-07 Impact factor: 3.490

2. L-amino acid ligase from Pseudomonas syringae producing tabtoxin can be used for enzymatic synthesis of various functional peptides.

Authors: Toshinobu Arai; Yasuhiro Arimura; Shun Ishikura; Kuniki Kino
Journal: Appl Environ Microbiol Date: 2013-06-14 Impact factor: 4.792

Review 3. Natural compounds as next-generation herbicides.

Authors: Franck E Dayan; Stephen O Duke
Journal: Plant Physiol Date: 2014-04-30 Impact factor: 8.340

4. A possible role for acetylated intermediates in diaminopimelate and tabtoxinine-beta-lactam biosynthesis in Pseudomonas syringae pv. tabaci BR2.024.

Authors: L Liu; P D Shaw
Journal: J Bacteriol Date: 1997-09 Impact factor: 3.490

5. Self-protection of Pseudomonas syringae pv. "tabaci" from its toxin, tabtoxinine-beta-lactam.

Authors: T J Knight; R D Durbin; P J Langston-Unkefer
Journal: J Bacteriol Date: 1987-05 Impact factor: 3.490

6. Role of glutamine synthetase adenylylation in the self-protection of Pseudomonas syringae subsp. "tabaci" from its toxin, tabtoxinine-beta-lactam.

Authors: T J Knight; R D Durbin; P J Langston-Unkefer
Journal: J Bacteriol Date: 1986-04 Impact factor: 3.490

Review 7. Small-Molecule Acetylation by GCN5-Related N-Acetyltransferases in Bacteria.

Authors: Rachel M Burckhardt; Jorge C Escalante-Semerena
Journal: Microbiol Mol Biol Rev Date: 2020-04-15 Impact factor: 11.056

8. The inactivation of ornithine transcarbamoylase by N delta-(N'-sulpho-diaminophosphinyl)-L-ornithine.

Authors: M D Templeton; R E Mitchell; P A Sullivan; M G Shepherd
Journal: Biochem J Date: 1985-06-01 Impact factor: 3.857

9. beta-Hydroxylation of the aspartyl residue in the phytotoxin syringomycin E: characterization of two candidate hydroxylases AspH and SyrP in Pseudomonas syringae.

Authors: Gitanjali M Singh; Pascal D Fortin; Alexander Koglin; Christopher T Walsh
Journal: Biochemistry Date: 2008-10-01 Impact factor: 3.162

10. A draft genome sequence and functional screen reveals the repertoire of type III secreted proteins of Pseudomonas syringae pathovar tabaci 11528.

Authors: David J Studholme; Selena Gimenez Ibanez; Daniel MacLean; Jeffery L Dangl; Jeff H Chang; John P Rathjen
Journal: BMC Genomics Date: 2009-08-24 Impact factor: 3.969