A receptor for plasminogen and plasmin on human and rat carcinoma cells. Evidence for strong interspecific reactivity.

We have previously demonstrated the existence of a receptor for plasmin and plasminogen on carcinoma cells, either from human or rat origin. We show here that these receptors have a strong interspecific reactivity. This conclusion is based on binding assay of 125I labelled plasminogens and fluorescence experiments using biotinylated human plasminogen. In all these experiments cells from one species could bind plasminogen from the other species and interspecific inhibition was observed as well.