Literature DB >> 1665783

Serotonin modulates muscimol- and baclofen-elicited inhibition of cerebellar Purkinje cells.

J C Strahlendorf1, M H Lee, H K Strahlendorf.   

Abstract

The present study was designed to test whether serotonin (5-HT) preferentially affects the GABAA or GABAB receptor subtypes in the cerebellum using muscimol and baclofen as the selective agonists. Serotonin significantly augmented baclofen- and muscimol-elicited inhibitions with minimal effects of 5-HT on the spontaneous activity. The magnitudes of augmentation of baclofen and muscimol effects seen in the presence of 5-HT were comparable. In summary, this study further describes the neuromodulatory role of serotonin on GABAergic inhibition and based upon the present study, it can be concluded that both GABAA and GABAB receptor subtypes are modulated by 5-HT.

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Year:  1991        PMID： 1665783     DOI： 10.1016/0014-2999(91)90352-q

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

1.  In vivo modulation of vagal-identified dorsal medullary neurones by activation of different 5-Hydroxytryptamine(2) receptors in rats.

Authors:  C Sévoz-Couche; K M Spyer; D Jordan
Journal:  Br J Pharmacol       Date:  2000-12       Impact factor: 8.739

2.  Serotonergic control of GABAergic inhibition in the lateral amygdala.

Authors:  Ryo Yamamoto; Takafumi Furuyama; Tokio Sugai; Munenori Ono; Denis Pare; Nobuo Kato
Journal:  J Neurophysiol       Date:  2019-12-25       Impact factor: 2.714

3.  Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice.

Authors:  Loai Alzghoul; Marco Bortolato; Foteini Delis; Panayotis K Thanos; Ryan D Darling; Sean C Godar; Junlin Zhang; Samuel Grant; Gene-Jack Wang; Kimberly L Simpson; Kevin Chen; Nora D Volkow; Rick C S Lin; Jean C Shih
Journal:  Neuropharmacology       Date:  2012-08-16       Impact factor: 5.250

4.  Serotonin-driven long-range inhibitory connections in the cerebellar cortex.

Authors:  S Dieudonné; A Dumoulin
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

5.  Methamphetamine facilitates ethanol-induced depressions in cerebellar Purkinje neurons of prazocin- or DSP4-treated rats.

Authors:  Y Wang; C H Jeng; J C Lin; J Y Wang
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530
  5 in total

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