Literature DB >> 1665728

The effects of lectins on the release of EDRF from rabbit aorta.

J F Kleha1, P Devesly, A Johns.   

Abstract

The effects of the lectins, wheat germ agglutinin (WGA) and concanavalin A (Con A) on endothelium intact pre-contracted rabbit aorta were investigated. WGA (8.3 microM) produced endothelium-dependent relaxations, while Con A (4.3 microM) produced a partially endothelium-dependent relaxation. The endothelium-dependent relaxations to WGA were completely reversed by N-acetylglucosamine, haemoglobin and methylene blue and were partially reversed by NG-monomethyl-L-arginine (L-NMMA). It is suggested that WGA works as an agonist in releasing endothelium-derived relaxing factor (EDRF) from the endothelium of rabbit aorta by interacting with a glycosylated receptor on endothelial cells.

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Year:  1991        PMID： 1665728      PMCID： PMC1908567          DOI： 10.1111/j.1476-5381.1991.tb12421.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  Endocytosis of wheat germ agglutinin binding sites from the cell surface into a tubular endosomal network.

Authors:  T J Raub; M J Koroly; R M Roberts
Journal:  J Cell Physiol       Date:  1990-04       Impact factor: 6.384

2.  LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase.

Authors:  A Mülsch; R Busse; S Liebau; U Förstermann
Journal:  J Pharmacol Exp Ther       Date:  1988-10       Impact factor: 4.030

Review 3.  The role of endothelium in the responses of vascular smooth muscle to drugs.

Authors:  R F Furchgott
Journal:  Annu Rev Pharmacol Toxicol       Date:  1984       Impact factor: 13.820

4.  Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors:  W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal:  J Pharmacol Exp Ther       Date:  1985-03       Impact factor: 4.030

5.  NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell.

Authors:  R A Johns; M J Peach; J Linden; A Tichotsky
Journal:  Circ Res       Date:  1990-10       Impact factor: 17.367

6.  Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187.

Authors:  B B Weksler; C W Ley; E A Jaffe
Journal:  J Clin Invest       Date:  1978-11       Impact factor: 14.808

7.  Wheat germ agglutinin inhibits thrombin-induced rises in cytosolic free calcium and prostacyclin synthesis by human umbilical vein endothelial cells.

Authors:  J Grulich-Henn; B B Weksler; K Watanabe; E A Jaffe
Journal:  J Cell Physiol       Date:  1988-12       Impact factor: 6.384

8.  Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.

Authors:  G de Nucci; R J Gryglewski; T D Warner; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
  8 in total
  2 in total

1.  EDRF release from canine coronary artery by lectins.

Authors:  J F Kleha; P Devesly; A Johns
Journal:  Br J Pharmacol       Date:  1993-12       Impact factor: 8.739

2.  Vasodilator effects of Diocleinae lectins from the Canavalia genus.

Authors:  Ana Maria Sampaio Assreuy; Sabrina Rodrigues Fontenele; Alana de Freitas Pires; Débora Costa Fernandes; Natália Velloso Fontenelle C Rodrigues; Eduardo Henrique Salviano Bezerra; Tales Rocha Moura; Kyria Santiago do Nascimento; Benildo Sousa Cavada
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2009-10-24       Impact factor: 3.000
  2 in total

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