| Literature DB >> 1665679 |
A Fernandez Rodriguez1, H Galera Davidson, M Salguero Villadiego, A Moreno Fernandez, I Martin Lacave, J Fernandez Sanz.
Abstract
This study was designed to investigate the histologic changes in goitrogen-induced thyroid growth of the rat. The animals were orally treated by 1% potassium perchlorate except the controls and were sacrificed in intervals ranging from 1 to 12 months. The thyroid weight increased progressively along the treatment and after 2 months showed a diffuse homogenous hypertrophy and hyperplasia of follicular cells, decreased amount of colloid and increased vascularity. After sixth month of treatment true nodules appeared with complex morphology.Entities:
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Year: 1991 PMID： 1665679 DOI： 10.1111/j.1439-0264.1991.tb00304.x
Source DB: PubMed Journal: Anat Histol Embryol ISSN： 0340-2096 Impact factor: 1.114