Literature DB >> 16650992

The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

Sergio A Alonso De Diego1, Marta Gutiérrez-Rodríguez, M Jesús Pérez de Vega, Rosario González-Muñiz, Rosario Herranz, Mercedes Martín-Martínez, Edurne Cenarruzabeitia, Diana Frechilla, Joaquín Del Río, M Luisa Jimeno, M Teresa García-López.   

Abstract

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.

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Year:  2006        PMID： 16650992     DOI： 10.1016/j.bmcl.2006.04.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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