| Literature DB >> 16650987 |
Dange Vijaykumar1, Roopa Rai, Michael Shaghafi, Tony Ton, Steve Torkelson, Ellen M Leahy, Jennifer R Riggs, Huiyong Hu, Paul A Sprengeler, William D Shrader, Colin O'Bryan, Ronnell Cabuslay, Ellen Sanford, Erik Gjerstadt, Liang Liu, Juthamas Sukbuntherng, Wendy B Young.
Abstract
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in improved physicochemical properties, leading to enhanced oral absorption in rat.Entities:
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Year: 2006 PMID： 16650987 DOI： 10.1016/j.bmcl.2006.04.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823