BACKGROUND: Cardiopulmonary exercise testing (CPX) clearly holds prognostic value in the heart failure (HF) population. Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CPX in a female HF group. METHODS: Seventy-five female and 337 male subjects diagnosed with HF participated in this study. The ability of peak oxygen consumption (VO(2)) and the minute ventilation/carbon dioxide production (VE/VCO(2)) slope to predict cardiac-related events were assessed. RESULTS: In the year following CPX, the female group suffered 26 cardiac-related events (8 deaths/18 hospitalizations), while the male group suffered 89 cardiac-related events (20 deaths/69 hospitalizations). The hazard ratios for peak VO(2) and the VE/VCO(2) slope were 4.0 (95% confidence interval: 2.6-6.1, p<0.001) and 4.2 (95% confidence interval: 2.7-6.6, p<0.001) in the male group and 3.8 (95% confidence interval: 1.7-8.5, p<0.001) and 4.3 (95% confidence interval: 1.8-9.8, p<0.001) in the female group. In both the male and female groups, Cox multivariate analysis revealed VE/VCO(2) slope was the strongest predictor of cardiac-related events while peak VO(2) added significant predictive value and was retained in the regression. CONCLUSION: The results of the present study indicate that the prognostic value of peak VO(2) and the VE/VCO(2) slope are similar in men and women diagnosed with HF. In both men and women, the prognostic power of the VE/VCO(2) slope is greater than that of peak VO(2).
BACKGROUND: Cardiopulmonary exercise testing (CPX) clearly holds prognostic value in the heart failure (HF) population. Studies investigating the prognostic value of CPX in individuals with HF have consistently examined predominantly male groups. The purpose of the present study was to examine the prognostic value of CPX in a female HF group. METHODS: Seventy-five female and 337 male subjects diagnosed with HF participated in this study. The ability of peak oxygen consumption (VO(2)) and the minute ventilation/carbon dioxide production (VE/VCO(2)) slope to predict cardiac-related events were assessed. RESULTS: In the year following CPX, the female group suffered 26 cardiac-related events (8 deaths/18 hospitalizations), while the male group suffered 89 cardiac-related events (20 deaths/69 hospitalizations). The hazard ratios for peak VO(2) and the VE/VCO(2) slope were 4.0 (95% confidence interval: 2.6-6.1, p<0.001) and 4.2 (95% confidence interval: 2.7-6.6, p<0.001) in the male group and 3.8 (95% confidence interval: 1.7-8.5, p<0.001) and 4.3 (95% confidence interval: 1.8-9.8, p<0.001) in the female group. In both the male and female groups, Cox multivariate analysis revealed VE/VCO(2) slope was the strongest predictor of cardiac-related events while peak VO(2) added significant predictive value and was retained in the regression. CONCLUSION: The results of the present study indicate that the prognostic value of peak VO(2) and the VE/VCO(2) slope are similar in men and women diagnosed with HF. In both men and women, the prognostic power of the VE/VCO(2) slope is greater than that of peak VO(2).
Authors: Ross Arena; Marco Guazzi; Jonathan Myers; Paul Chase; Daniel Bensimhon; Lawrence P Cahalin; Mary Ann Peberdy; Euan Ashley; Erin West; Daniel E Forman Journal: Congest Heart Fail Date: 2012-04-26
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Authors: Ross Arena; Jonathan Myers; Joshua Abella; Sherry Pinkstaff; Peter Brubaker; Dalane W Kitzman; Mary Ann Peberdy; Daniel Bensimhon; Paul Chase; Marco Guazzi Journal: Int J Cardiol Date: 2010-06-30 Impact factor: 4.164
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Authors: James E Peterman; Ross Arena; Jonathan Myers; Susan Marzolini; Philip A Ades; Patrick D Savage; Carl J Lavie; Leonard A Kaminsky Journal: J Am Heart Assoc Date: 2021-11-08 Impact factor: 5.501
Authors: Elisabetta Salvioni; Ugo Corrà; Massimo Piepoli; Sara Rovai; Michele Correale; Stefania Paolillo; Mario Pasquali; Damiano Magrì; Giuseppe Vitale; Laura Fusini; Massimo Mapelli; Carlo Vignati; Rocco Lagioia; Rosa Raimondo; Gianfranco Sinagra; Federico Boggio; Lorenzo Cangiano; Giovanna Gallo; Alessandra Magini; Mauro Contini; Pietro Palermo; Anna Apostolo; Beatrice Pezzuto; Alice Bonomi; Angela B Scardovi; Pasquale Perrone Filardi; Giuseppe Limongelli; Marco Metra; Domenico Scrutinio; Michele Emdin; Lucrezia Piccioli; Carlo Lombardi; Gaia Cattadori; Gianfranco Parati; Sergio Caravita; Federica Re; Mariantonietta Cicoira; Maria Frigerio; Francesco Clemenza; Maurizio Bussotti; Elisa Battaia; Marco Guazzi; Francesco Bandera; Roberto Badagliacca; Andrea Di Lenarda; Giuseppe Pacileo; Claudio Passino; Susanna Sciomer; Giuseppe Ambrosio; Piergiuseppe Agostoni Journal: ESC Heart Fail Date: 2020-01-01