BACKGROUND: Although the dematiaceous fungus Veronaea botryosa is rarely encountered clinically, it can be pathogenic. METHODS: A patient with a history of diabetes mellitus, coronary artery disease, and Cushing's syndrome had recurrent multifocal, crusted, brownish-red noduloplaques on the right forearm, left upper limb, and right knee. A skin biopsy was obtained for histopathology and fungal cultures. RESULTS: The histopathology showed brownish hyphae and yeast-like cells scattered in granulomatous infiltrates. Slide cultures revealed erect and straight conidiophores with two-celled cylindrical conidia, which have round tops and truncated bases. The fungus was identified as Veronaea botryosa. The disease slowly progressed despite a 6-month itraconazole regimen (200 mg daily). Subsequent use of Amphoterecin B produced only mild clinical improvements. Susceptibility tests showed resistance to both agents. CONCLUSIONS: Cutaneous phaeohyphomycosis caused by V. botryosa is extremely rare. Antifungal susceptibility tests are important for choosing the appropriate drug and predicting the clinical outcome.
BACKGROUND: Although the dematiaceous fungus Veronaea botryosa is rarely encountered clinically, it can be pathogenic. METHODS: A patient with a history of diabetes mellitus, coronary artery disease, and Cushing's syndrome had recurrent multifocal, crusted, brownish-red noduloplaques on the right forearm, left upper limb, and right knee. A skin biopsy was obtained for histopathology and fungal cultures. RESULTS: The histopathology showed brownish hyphae and yeast-like cells scattered in granulomatous infiltrates. Slide cultures revealed erect and straight conidiophores with two-celled cylindrical conidia, which have round tops and truncated bases. The fungus was identified as Veronaea botryosa. The disease slowly progressed despite a 6-month itraconazole regimen (200 mg daily). Subsequent use of Amphoterecin B produced only mild clinical improvements. Susceptibility tests showed resistance to both agents. CONCLUSIONS:Cutaneous phaeohyphomycosis caused by V. botryosa is extremely rare. Antifungal susceptibility tests are important for choosing the appropriate drug and predicting the clinical outcome.
Authors: Alexandro Bonifaz; Mehrnaz Mohammad Davoudi; G S de Hoog; Carmen Padilla-Desgarennes; Denisse Vázquez-González; Gisela Navarrete; Jacques F Meis; Hamid Badali Journal: Mycopathologia Date: 2013-03-08 Impact factor: 2.574
Authors: Mariana Machado Fidelis do Nascimento; G Sybren de Hoog; Renata Rodrigues Gomes; Jason Lee Furuie; Jane Mary Lafayette Gelinski; Mohammad Javad Najafzadeh; Walter Antonio Pereira Boeger; Vania Aparecida Vicente Journal: Mycopathologia Date: 2016-03-30 Impact factor: 2.574
Authors: Hamid Badali; Seyed Amir Yazdanparast; Alexandro Bonifaz; Bita Mousavi; G Sybren de Hoog; Corné H W Klaassen; Jacques F Meis Journal: Mycopathologia Date: 2013-03-06 Impact factor: 2.574
Authors: Rachel D Brownlee; Denise M Imai; Denver J Coleman; Amir Ardeshir; Samah M R Abdelrazek; Esteban Soto Journal: Comp Med Date: 2019-08-06 Impact factor: 0.982
Authors: Anne Welfringer; Valérie Vuong; Nicolas Argy; Christian Chochillon; Lydia Deschamps; Guillaume Rollin; Stanislas Harent; Véronique Joly; William Vindrios; Vincent Descamps Journal: Med Mycol Case Rep Date: 2017-02-05