Literature DB >> 16649533

Beta3-adrenergic stimulation in the human heart: signal transduction, functional implications and therapeutic perspectives.

C Pott1, K Brixius, W Bloch, C Ziskoven, A Napp, R H G Schwinger.   

Abstract

Next to beta1- and beta2-adrenoceptors, a third beta-adrenoceptor population is expressed in the human heart, the beta3-adrenoceptor. In mammalian ventricular myocytes, beta3-adrenergic stimulation leads to a decrease in contractility via a release of nitric oxide (NO). Recently, different molecular mechanisms of beta3-adrenergic activation of endothelial nitric oxide synthase (eNOS) have been uncovered in cardiac myocytes. In the non-failing and especially the failing heart, beta3-adrenergic stimulation may offer protection against excessive catecholaminergic beta1-adrenoceptor stimulation. In this context, the beta3-adrenoceptor is discussed as a novel target for the pharmacological therapy of heart failure.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16649533

Source DB:  PubMed          Journal:  Pharmazie        ISSN： 0031-7144            Impact factor:   1.267


  6 in total

1.  Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.

Authors:  An L Moens; Jordan S Leyton-Mange; Xiaolin Niu; Ronghua Yang; Oscar Cingolani; Elisabeth K Arkenbout; Hunter C Champion; Djahida Bedja; Kathleen L Gabrielson; Juan Chen; Yong Xia; Ashley B Hale; Keith M Channon; Marc K Halushka; Norman Barker; Floris L Wuyts; Pawel M Kaminski; Michael S Wolin; David A Kass; Lili A Barouch
Journal:  J Mol Cell Cardiol       Date:  2009-09-18       Impact factor: 5.000

2.  Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice.

Authors:  C Pott; L Willkomm; S Grafweg; B Bölck; G W Dorn; R H G Schwinger; K Brixius
Journal:  Mol Cell Biochem       Date:  2008-05-13       Impact factor: 3.396

3.  Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 1) fat store depletion and desensitization of beta-adrenergic responses.

Authors:  C Ferrand; A Redonnet; D Prévot; C Carpéné; C Atgié
Journal:  J Physiol Biochem       Date:  2006-06       Impact factor: 5.080

Review 4.  The current status of beta blockers' use in the management of hypertension.

Authors:  Shahid Akbar; Mohammad S Alorainy
Journal:  Saudi Med J       Date:  2014-11       Impact factor: 1.484

5.  Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study.

Authors:  Tomoya Nakano; Kenji Onoue; Yasuki Nakada; Hitoshi Nakagawa; Takuya Kumazawa; Tomoya Ueda; Taku Nishida; Tsunenari Soeda; Satoshi Okayama; Makoto Watanabe; Hiroyuki Kawata; Rika Kawakami; Manabu Horii; Hiroyuki Okura; Shiro Uemura; Kinta Hatakeyama; Yasuhiro Sakaguchi; Yoshihiko Saito
Journal:  Sci Rep       Date:  2018-08-24       Impact factor: 4.379

6.  The Regulator of G Protein Signaling Homologous Domain of G Protein-Coupled Receptor Kinase 2 Mediates Short-Term Desensitization of β3-Adrenergic Receptor.

Authors:  Emiliana Echeverría; Maia Cabrera; Valeria Burghi; Máximo Sosa; Sonia Ripoll; Agustín Yaneff; Federico Monczor; Carlos Davio; Carina Shayo; Natalia Fernández
Journal:  Front Pharmacol       Date:  2020-02-21       Impact factor: 5.810
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.