Literature DB >> 1664942

Stimulatory and inhibitory actions of VIP and cyclic AMP on cytoplasmic Ca2+ signal generation in pancreatic acinar cells.

H Kase1, M Wakui, O H Petersen.   

Abstract

In pancreatic acinar cells the effects of vasoactive intestinal polypeptide (VIP) and dibutyryl cyclic AMP (dbcAMP) alone and during stimulation with acetylcholine (ACh) or internally applied inositol trisphosphate (InsP3) were investigated utilizing the patch-clamp whole-cell current recording configuration to assess changes in cytoplasmic Ca2+ concentration by measurement of Ca2+ dependent Cl- current. VIP (1 nM) and dbcAMP (0.5 mM) each evoked repetitive pulses of Ca(2+)-dependent Cl- current. A high VIP concentration (100 nM) acutely and reversibly inhibited the responses evoked by 1 nM VIP and also acutely inhibited ACh-evoked responses. DbcAMP (2 mM) also reversibly inhibited the ACh-evoked responses. Neither VIP nor dbcAMP were able to inhibit InsP3-evoked repetitive Ca2+ pulses. VIP in a low concentration can generate cytosolic Ca2+ oscillations via cyclic AMP, but high VIP concentrations inhibit both ACh and VIP-evoked Ca2+ signals and this effect is mediated by high intracellular cyclic AMP levels.

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Year:  1991        PMID： 1664942     DOI： 10.1007/bf00370314

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  7 in total

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Authors:  A Schmid; M Dehlinger-Kremer; I Schulz; H Gögelein
Journal:  Nature       Date:  1990-07-26       Impact factor: 49.962

Review 2.  Oscillating intracellular Ca2+ signals evoked by activation of receptors linked to inositol lipid hydrolysis: mechanism of generation.

Authors:  O H Petersen; M Wakui
Journal:  J Membr Biol       Date:  1990-11       Impact factor: 1.843

3.  Phosphorylation of the cardiac ryanodine receptor by cAMP-dependent protein kinase.

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Journal:  J Biochem       Date:  1989-11       Impact factor: 3.387

4.  Receptor-activated cytoplasmic Ca2+ spiking mediated by inositol trisphosphate is due to Ca2(+)-induced Ca2+ release.

Authors:  M Wakui; Y V Osipchuk; O H Petersen
Journal:  Cell       Date:  1990-11-30       Impact factor: 41.582

5.  Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.

Authors:  H Streb; R F Irvine; M J Berridge; I Schulz
Journal:  Nature       Date:  1983 Nov 3-9       Impact factor: 49.962

6.  Cyclic AMP-evoked oscillations of intracellular [Ca2+] in guinea-pig hepatocytes.

Authors:  T Capiod; J Noel; L Combettes; M Claret
Journal:  Biochem J       Date:  1991-04-01       Impact factor: 3.857

7.  Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells.

Authors:  Y V Osipchuk; M Wakui; D I Yule; D V Gallacher; O H Petersen
Journal:  EMBO J       Date:  1990-03       Impact factor: 11.598
  7 in total
  9 in total

Review 1.  Is the intrasomal phase of fast axonal transport driven by oscillations of intracellular calcium?

Authors:  R Hammerschlag
Journal:  Neurochem Res       Date:  1994-11       Impact factor: 3.996

2.  Simultaneous presence of cAMP and cGMP exert a co-ordinated inhibitory effect on the agonist-evoked Ca2+ signal in pancreatic acinar cells.

Authors:  P J Camello; O H Petersen; E C Toescu
Journal:  Pflugers Arch       Date:  1996-09       Impact factor: 3.657

3.  VIP and muscarinic synergistic mucin secretion by salivary mucous cells is mediated by enhanced PKC activity via VIP-induced release of an intracellular Ca2+ pool.

Authors:  David J Culp; Z Zhang; R L Evans
Journal:  Pflugers Arch       Date:  2020-01-13       Impact factor: 3.657

4.  Interactions between secretin and acetylcholine in the regulation of fluid secretion by isolated rat pancreatic ducts.

Authors:  R L Evans; N Ashton; A C Elliott; R Green; B E Argent
Journal:  J Physiol       Date:  1996-10-01       Impact factor: 5.182

5.  Cyclic AMP accelerates calcium waves in pancreatic acinar cells.

Authors:  Ahsan U Shah; Wayne M Grant; Sahibzada U Latif; Zahir M Mannan; Alexander J Park; Sohail Z Husain
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-04-03       Impact factor: 4.052

6.  Characterisation of volume-activated ion transport across epithelial monolayers of human intestinal T84 cells.

Authors:  G T McEwan; C D Brown; B H Hirst; N L Simmons
Journal:  Pflugers Arch       Date:  1993-05       Impact factor: 3.657

7.  Cytosolic Ca2+ spikes evoked by the thiol reagent thimerosal in both intact and internally perfused single pancreatic acinar cells.

Authors:  P Thorn; P Brady; J Llopis; D V Gallacher; O H Petersen
Journal:  Pflugers Arch       Date:  1992-11       Impact factor: 3.657

8.  Effect of vasoactive intestinal peptide, carbachol and other agonists on the membrane voltage of pancreatic duct cells.

Authors:  C Pahl; I Novak
Journal:  Pflugers Arch       Date:  1993-08       Impact factor: 3.657

9.  A voltage-sensitive transient potassium current in mouse pancreatic acinar cells.

Authors:  P Thorn; O H Petersen
Journal:  Pflugers Arch       Date:  1994-10       Impact factor: 3.657
  9 in total

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