| Literature DB >> 16648847 |
Dar Meshi1, Michael R Drew, Michael Saxe, Mark S Ansorge, Denis David, Luca Santarelli, Chariklia Malapani, Holly Moore, René Hen.
Abstract
Environmental enrichment increases adult hippocampal neurogenesis and alters hippocampal-dependent behavior in rodents. To investigate a causal link between these two observations, we analyzed the effect of enrichment on spatial learning and anxiety-like behavior while blocking adult hippocampal neurogenesis. We report that environmental enrichment alters behavior in mice regardless of their hippocampal neurogenic capability, providing evidence that the newborn cells do not mediate these effects of enrichment.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16648847 DOI： 10.1038/nn1696
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884