OBJECTIVE: It has been well acknowledged that hypoglycemia induces cognitive impairment. However, the behavior of hippocampal cholinergic system, which is thought to play a key role in cognition, during hypoglycemia remains to be elucidated. MATERIALS AND METHODS: In this study we conducted a microdialysis using 9 weeks old virgin male Wistar/ST rats to determine the changes of extracelluar acethylcholine and glucose levels in the hippocampus during insulin-induced severe hypoglycemia, and compared the results with those obtained from a microdialysis in the striatum. RESULTS: The extracelluar concentrations of acethylcholine both in the hippocampus and striatum did not change during hypoglycemia. CONCLUSION: The results of the present study may suggest that changes of hippocampal cholinergic release may not be involved in the mechanism of cognitive impairment during hypoglycemia.
OBJECTIVE: It has been well acknowledged that hypoglycemia induces cognitive impairment. However, the behavior of hippocampal cholinergic system, which is thought to play a key role in cognition, during hypoglycemia remains to be elucidated. MATERIALS AND METHODS: In this study we conducted a microdialysis using 9 weeks old virgin male Wistar/ST rats to determine the changes of extracelluar acethylcholine and glucose levels in the hippocampus during insulin-induced severe hypoglycemia, and compared the results with those obtained from a microdialysis in the striatum. RESULTS: The extracelluar concentrations of acethylcholine both in the hippocampus and striatum did not change during hypoglycemia. CONCLUSION: The results of the present study may suggest that changes of hippocampal cholinergic release may not be involved in the mechanism of cognitive impairment during hypoglycemia.
Authors: Cornelia Kiewert; Alexander Mdzinarishvili; Joachim Hartmann; Ulrich Bickel; Jochen Klein Journal: Brain Res Date: 2009-12-02 Impact factor: 3.252