OBJECTIVE: One-third of patients with a schizophrenia spectrum disorder have a measurable olfactory identification deficit at first examination. The authors studied the relationship of this deficit to symptom remission after 1 year of treatment. METHOD: Fifty-eight patients naive to antipsychotic medication who entered the Nova Scotia Early Psychosis Program were symptomatically rated with the Positive and Negative Syndrome Scale (PANSS) (at baseline and 1 year). At baseline, the University of Pennsylvania Smell Identification Test (UPSIT) was also completed. Remission was determined for four symptom factors derived from the PANSS (positive, negative, cognitive/disorganized, and anxiety/depression). Patients with and without remission were compared on UPSIT scores. RESULTS: Patients with nonremission of negative and cognitive/disorganized symptoms had significantly lower baseline UPSIT scores compared with patients with remission. UPSIT scores were unrelated to remission of positive or anxiety/depression symptoms. CONCLUSIONS: UPSIT scores can be used to identify patients at risk for persistent negative and disorganized/cognitive symptoms.
OBJECTIVE: One-third of patients with a schizophrenia spectrum disorder have a measurable olfactory identification deficit at first examination. The authors studied the relationship of this deficit to symptom remission after 1 year of treatment. METHOD: Fifty-eight patients naive to antipsychotic medication who entered the Nova Scotia Early Psychosis Program were symptomatically rated with the Positive and Negative Syndrome Scale (PANSS) (at baseline and 1 year). At baseline, the University of Pennsylvania Smell Identification Test (UPSIT) was also completed. Remission was determined for four symptom factors derived from the PANSS (positive, negative, cognitive/disorganized, and anxiety/depression). Patients with and without remission were compared on UPSIT scores. RESULTS:Patients with nonremission of negative and cognitive/disorganized symptoms had significantly lower baseline UPSIT scores compared with patients with remission. UPSIT scores were unrelated to remission of positive or anxiety/depression symptoms. CONCLUSIONS: UPSIT scores can be used to identify patients at risk for persistent negative and disorganized/cognitive symptoms.
Authors: Vidyulata Kamath; Bruce I Turetsky; Monica E Calkins; Christian G Kohler; Catherine G Conroy; Karin Borgmann-Winter; Dana E Gatto; Raquel E Gur; Paul J Moberg Journal: World J Biol Psychiatry Date: 2011-11-10 Impact factor: 4.132
Authors: Martin Schecklmann; Christina Schwenck; Regina Taurines; Christine Freitag; Andreas Warnke; Manfred Gerlach; Marcel Romanos Journal: J Neural Transm (Vienna) Date: 2012-07-19 Impact factor: 3.575
Authors: Mary R Lee; Heidi J Wehring; Robert P McMahon; Jared Linthicum; Nicola Cascella; Fang Liu; Alan Bellack; Robert W Buchanan; Gregory P Strauss; Carlo Contoreggi; Deanna L Kelly Journal: Schizophr Res Date: 2013-02-13 Impact factor: 4.939
Authors: Jürgen Kayser; Craig E Tenke; Christopher J Kroppmann; Daniel M Alschuler; Shelly Ben-David; Shiva Fekri; Gerard E Bruder; Cheryl M Corcoran Journal: Int J Psychophysiol Date: 2013-07-13 Impact factor: 2.997