Literature DB >> 1664775

Separation of alpha 1, alpha 2 and alpha 3 subunits of the GABAA-benzodiazepine receptor complex by immunoaffinity chromatography.

J Zezula1, K Fuchs, W Sieghart.   

Abstract

Polyclonal antibodies raised to synthetic amino acid sequences of the rat gamma-aminobutyric acid (GABAA) receptor alpha 1-, alpha 2- and alpha 3-subunits selectively recognized single proteins with apparent molecular weight 51 kDa (P51), 53 kDa (P53) and 59 kDa (P59), respectively, in GABAA receptor preparations affinity purified from the brains of 5-10-day-old rats. The antibodies were coupled to Affigel 10, and the resulting immunoaffinity columns were used to isolate these proteins from affinity purified GABAA receptors.

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Year:  1991        PMID： 1664775     DOI： 10.1016/0006-8993(91)91556-g

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  12 in total

1.  Functional correlation of GABA(A) receptor alpha subunits expression with the properties of IPSCs in the developing thalamus.

Authors:  M Okada; K Onodera; C Van Renterghem; W Sieghart; T Takahashi
Journal:  J Neurosci       Date:  2000-03-15       Impact factor: 6.167

2.  Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells.

Authors:  Z Nusser; W Sieghart; P Somogyi
Journal:  J Neurosci       Date:  1998-03-01       Impact factor: 6.167

3.  Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells.

Authors:  Z Nusser; W Sieghart; D Benke; J M Fritschy; P Somogyi
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

4.  α2 Subunit-Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus.

Authors:  A Kerstin Lindemeyer; Yi Shen; Ferin Yazdani; Xuesi M Shao; Igor Spigelman; Daryl L Davies; Richard W Olsen; Jing Liang
Journal:  Mol Pharmacol       Date:  2017-05-23       Impact factor: 4.436

5.  The effect of GABA stimulation on GABAA receptor subunit protein and mRNA expression in rat cultured cerebellar granule cells.

Authors:  K P Platt; R E Zwartjes; D R Bristow
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

6.  Synaptic input of ON-bipolar cells onto the dopaminergic neurons of the mouse retina.

Authors:  Massimo Contini; Bin Lin; Kazuto Kobayashi; Hideyuki Okano; Richard H Masland; Elio Raviola
Journal:  J Comp Neurol       Date:  2010-06-01       Impact factor: 3.215

7.  Ethanol-induced plasticity of GABAA receptors in the basolateral amygdala.

Authors:  A Kerstin Lindemeyer; Jing Liang; Vincent N Marty; Edward M Meyer; Asha Suryanarayanan; Richard W Olsen; Igor Spigelman
Journal:  Neurochem Res       Date:  2014-04-08       Impact factor: 3.996

8.  Cell type- and input-specific differences in the number and subtypes of synaptic GABA(A) receptors in the hippocampus.

Authors:  Thomas Klausberger; J David B Roberts; Peter Somogyi
Journal:  J Neurosci       Date:  2002-04-01       Impact factor: 6.167

9.  gamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus.

Authors:  J L Do-Rego; G A Mensah-Nyagan; D Beaujean; D Vaudry; W Sieghart; V Luu-The; G Pelletier; H Vaudry
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

10.  Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits.

Authors:  M Jechlinger; R Pelz; V Tretter; T Klausberger; W Sieghart
Journal:  J Neurosci       Date:  1998-04-01       Impact factor: 6.167
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